Clinical characteristics and prevalence of adenovirus with respiratory tract infections in children

中国小儿急救医学 Pub Date : 2020-02-20 DOI:10.3760/CMA.J.ISSN.1673-4912.2020.02.009

Jie Lin, Q. Cao, Bi-ru Li, M. Tang, L. Luo

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引用次数: 2

Abstract

Objective To explore the clinical characteristics prevalence of respiratory adenovirus infections in children, and to provide reference for diagnosis, monitoring and timely treatment. Methods A total of 775 clinical specimens were collected from Shanghai Children′s Medical Center during November 2016 to November 2017, and 84 cases of adenovirus infections were detected by FilmArray. Results Among 775 samples, 84 samples(10.8%) were adenovirus positive.The epidemic peak of adenovirus infection was winter, spring and summer, especially in winter(20.8%), and the highest detection rate was in January(32.2%). The age ranged from 6 months to 2 years(47.7%). The common clinical manifestations are fever(91.7%), cough(96.4%), wheezing(48.8%), and shortness of breath(14.2%). A total of 15 cases(17.9%) had underlying diseases, the most of them were congenital heart diseases(9 cases, 10.7%). A total of 53 cases(63.1%) were mixed infection, and 21 cases(25.0%) were complicated with human rhinovirus/enterovirus.There were 5 cases of upper respiratory tract infection, 3 cases of bronchitis and 76 cases of pneumonia, including 55 cases of mild pneumonia and 21 cases of severe pneumonia.The average length of hospital stay was 8.3 days.The length of hospital stay, cases of wheezing and severe cases in the mixed infection group were significantly higher than those in the single infection group(P<0.05). Hospitalization days, wheezing symptoms, extrapulmonary symptoms, basic diseases and mixed infections in severe group were significantly higher than those in mild group(P<0.05). Conclusion Adenovirus infection occurs in children aged 6 months to 2 years, with a high incidence in winter, spring and summer.The peak month is January.The main clinical manifestations are high fever, cough and wheezing.Children with underlying diseases, wheezing symptoms, extrapulmonary symptoms and mixed infections are more likely to develop severe diseases.FilmArray detection system can quickly and accurately detect pathogens, provide a good basis for early diagnosis, monitoring and treatment of clinicians. Key words: Adenovirus; Epidemiology; Clinical characteristics; Children; FilmArray detection

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儿童呼吸道感染腺病毒的临床特点及流行情况

目的探讨儿童呼吸道腺病毒感染的临床特点、患病率，为诊断、监测和及时治疗提供参考。方法2016年11月至2017年11月，从上海儿童医学中心采集775份临床标本，采用FilmArray检测84例腺病毒感染病例。结果775例标本中腺病毒阳性84例（10.8%）。腺病毒感染的流行高峰在冬季、春季和夏季，尤其是冬季（20.8%），1月检出率最高（32.2%）。年龄6个月至2岁（47.7%）。常见临床表现为发热（91.7%）、咳嗽（96.4%）、喘息（48.8%）和气短（14.2%）。共有15例（17.9%）有基础疾病，其中先天性心脏病9例（10.7%），混合感染53例（63.1%），并发人鼻病毒/肠道病毒21例（25.0%），上呼吸道感染5例，支气管炎3例，肺炎76例，其中轻度肺炎55例，重型肺炎21例。平均住院时间为8.3天。混合感染组的住院时间、喘息次数和重症明显高于单一感染组（P<0.05），结论腺病毒感染发生于6个月～2岁儿童，冬、春、夏高发。高峰月份为1月，主要临床表现为高热、咳嗽、喘息。有潜在疾病、喘息症状、肺外症状和混合感染的儿童更容易患上严重疾病。FilmArray检测系统可以快速准确地检测病原体，为临床医生的早期诊断、监测和治疗提供良好的基础。关键词：腺病毒；流行病学；临床特征；儿童；FilmArray检测

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来源期刊

中国小儿急救医学

自引率

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发文量

6226

期刊介绍： Chinese Journal of Neurology was established in 1955, the predecessor of which is Chinese Journal of Neurology and Psychiatry. Chinese Journal of Neurology and Psychiatry has been indexed by MEDLINE until 1996, when it was divided into two journals, Chinese Journal of Neurology, and Chinese Journal of Psychiatry. Chinese Journal of Neurology is now indexed by EM, SCOPUS, AJ, WPRIM, CNKI, Wanfang Data, CSCD, etc. The impact factor of the journal is 2.755 in 2017, ranking the first among all neurological and psychological journals in China and among all the 142 medical journals published by the Chinese Medical Association. The journal is available both in print and online.