Mitochondrial respiratory chain deficiency in older men and its relationship with muscle mass and performance

Abstract

Sarcopenia is the loss of muscle mass and physical performance with age, and recognition of its importance in clinical practice is growing. Age‐related decline in muscle mitochondrial function has been described although less is known about the role of mitochondrial dysfunction in sarcopenia. The aim of this study was to investigate whether respiratory chain deficiency is associated with muscle mass and physical performance among a sample of healthy older men participating in the Hertfordshire Sarcopenia Study.