Janus face of sepsis: a viewpoint

M. Bauer, R. Wetzker
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引用次数: 0

Abstract

Treatment of sepsis currently relies on eliminating the causal pathogen and supportive care, whereas almost no approaches to interfere with the defining event of a “dysregulated host response” are available. This review points to the striking correlation of two phenotypes of sepsis etiopathology with the concept of bipartite response patterns of higher organisms to microbial attacks. According to this concept, the phenotypes of sepsis can be interpreted as either resistance or tolerance responses to infection that got out of hand. This concept might allow focusing sepsis research and related patient studies on key conundrums of current sepsis research: how do resistance responses result in immunopathology and how can tolerance lead to systemic immunosuppression or even immunoparalysis? The heuristic vigor of these questions might inspire experimental efforts and clinical studies and ultimately advance the therapeutic armamentarium for sepsis care.
Janus面对败血症:一个观点
脓毒症的治疗目前依赖于消除致病病原体和支持性护理,而几乎没有任何方法可以干扰“宿主反应失调”的定义事件。这篇综述指出两种表型的脓毒症病因病理学的显著相关性与高等生物对微生物攻击的两部分反应模式的概念。根据这一概念,败血症的表型可以解释为对感染失控的耐药性或耐受性反应。这一概念可能使脓毒症研究和相关患者研究聚焦于当前脓毒症研究的关键难题:耐药反应如何导致免疫病理,耐受性如何导致全身免疫抑制甚至免疫瘫痪?这些问题的启发式活力可能会激发实验努力和临床研究,并最终推进败血症护理的治疗手段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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