Exosomes as delivery tools in cancer therapy: Future perspectives

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
Fatma Kubra Ata, S. Yalçın
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引用次数: 0

Abstract

Exosomes, which are one of the extracellular vesicles, are considered necessary tools of intracellular communication that abundant in our body in physiological and pathological conditions with a diameter of 30-150 nm. The nanotubes, dendrimeric, metallic, nanoparticles have been used in the medical area.  However, these nano-based systems are lack of standardized manufacturing methods and therefore, it has toxic effects on cells. The delivery methods of growth factors, exosomes, cells, and engineered tissues have notably advanced in the medical area. The fact that they contain bioactive molecules such as protein, lipid, RNA and DNA revealed that these structures may play an important role in the treatment of cancer. Here, we review work on the contribution exosomal mediated cancer treatment in two main topics as exogenous molecule carrier and self-use. We also emphasize the development of exosome-based systems by referring to the advantages and disadvantages of using exosomes and future perspectives in cancer therapy.
外泌体作为癌症治疗的递送工具:未来展望
外泌体是细胞外囊泡之一,被认为是生理和病理条件下细胞内通讯的必要工具,其直径为30- 150nm。纳米管、枝晶、金属、纳米颗粒等材料已广泛应用于医学领域。然而,这些基于纳米的系统缺乏标准化的制造方法,因此,它对细胞有毒性作用。生长因子、外泌体、细胞和工程组织的递送方法在医学领域取得了显著进展。它们含有生物活性分子,如蛋白质、脂质、RNA和DNA,这一事实表明,这些结构可能在癌症治疗中发挥重要作用。本文从外泌体作为外源分子载体和自身使用两方面综述了外泌体对肿瘤治疗的贡献。我们还通过参考使用外泌体的优点和缺点以及未来在癌症治疗中的展望,强调了基于外泌体的系统的发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
自引率
0.00%
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0
审稿时长
12 weeks
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