Advances in research of histone deacetylase inhibitors in treatment of hematological diseases

国际输血及血液学杂志 Pub Date : 2018-11-20 DOI:10.3760/CMA.J.ISSN.1673-419X.2018.06.013

D. Zheng

引用次数: 0

Abstract

Histone acetyltransferase (HAT) and histone deacetylase (HDAC) are involved in cell cycle regulation, cell proliferation and survival, cell differentiation, cell metabolism, protein trafficking, DNA repair and angiogenesis. Imbalance of HAT and HDAC is associated with the occurrence of some tumors. Therefore, various targeted drugs targeting the HDAC family may be effective for tumor treatment. This article will review the progress of chidamide, compared with the other histone deacetylase inhibitor (HDACi), in the treatment of hematological diseases such as lymphoma, leukemia, myelodysplastic syndrome (MDS), and multiple myeloma (MM). And these new drugs can serve the clinical practice in a better way. Key words: Histone deacetylase inhibitors; Hematologic neoplasms; Molecular targeted therapy; Chidamide; Treatment

查看原文本刊更多论文

组蛋白脱乙酰酶抑制剂治疗血液病的研究进展

组蛋白乙酰转移酶（HAT）和组蛋白脱乙酰酶（HDAC）参与细胞周期调节、细胞增殖和存活、细胞分化、细胞代谢、蛋白质运输、DNA修复和血管生成。HAT和HDAC的失衡与某些肿瘤的发生有关。因此，针对HDAC家族的各种靶向药物可能对肿瘤治疗有效。本文将综述四酰胺与其他组蛋白脱乙酰酶抑制剂（HDACi）在治疗淋巴瘤、白血病、骨髓增生异常综合征（MDS）和多发性骨髓瘤（MM）等血液病方面的进展。这些新药可以更好地为临床实践服务。关键词：组蛋白脱乙酰酶抑制剂；血液肿瘤；分子靶向治疗；奇达米德；治疗

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

国际输血及血液学杂志

自引率

0.00%

发文量

10610

期刊介绍： The International Journal of Transfusion and Hematology was founded in September 1978. It is a comprehensive academic journal in the field of transfusion and hematology, supervised by the National Health Commission and co-sponsored by the Chinese Medical Association, West China Second Hospital of Sichuan University, and the Institute of Transfusion Medicine of the Chinese Academy of Medical Sciences. The journal is a comprehensive academic journal that combines the basic and clinical aspects of transfusion and hematology and is publicly distributed at home and abroad. The International Journal of Transfusion and Hematology mainly reports on the basic and clinical scientific research results and progress in the field of transfusion and hematology, new experiences, new methods, and new technologies in clinical diagnosis and treatment, introduces domestic and foreign research trends, conducts academic exchanges, and promotes the development of basic and clinical research in the field of transfusion and hematology.