Brain glucose metabolism network and connectivity in patients with somatoform disorders

中华核医学与分子影像杂志 Pub Date : 2020-01-25 DOI:10.3760/CMA.J.ISSN.2095-2848.2020.01.002

Zhiwei Pan, Jianfei Xiao, Qi Huang, Donglang Jiang, Shuhua Ren, Y. Guan, F. Xie, Da-liang Sun, Fengchun Hua

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Abstract

Objective To observe the alteration of brain glucose metabolic network in patients with somatoform disorders (SFD). Methods 18F-fluorodeoxyglucose (FDG) PET images of 18 SFD patients (10 males, 8 females; age: (39.5±12.0) years; illness duration: (3.67±3.20) years) and 21 matched healthy controls (13 males, 8 females; age: (43.9±8.4) years) in Huashan Hospital of Fudan University from October 2011 to December 2012 were enrolled to construct the brain glucose metabolic networks for 2 groups (SFD group, control group) respectively. Then the global network properties (normalized clustering coefficient, normalized shortest path length, small-worldness and global efficiency) and local parameters (clustering coefficient and betweenness centrality of the node) were calculated using the graph theory. Differences between 2 groups were compared by permutation test with 1 000 permutations. The top 20% (18/90) were classified as Hub nodes based on the results of clustering coefficient and betweenness centrality of the node. Results Small-worldness of SFD patients was similar to that of healthy controls (σ>1). There were decreased tendency in normalized clustering coefficient and global efficiency, and increased tendency in normalized shortest path length in SFD patients, but without significant differences (P>0.05). Compared to healthy controls, the betweenness centrality of left pallidum, left amygdala, left precuneus and right angular gyrus increased (permutation test, P<0.05); the betweenness centrality of left middle temporal gyrus, right superior occipital gyrus decreased (permutation test, P<0.05); the clustering coefficients of bilateral pallidum, bilateral thalamus, and left amygdala decreased (permutation test, P<0.05). Most changed Hub nodes (16/24) belonged to limbic system. Conclusion The changes of topological properties of brain glucose metabolic network in SFD patients including the decreased tendency of small-worldness and global efficiency, as well as the altered Hub nodes, may provide valid imaging evidences for brain dysfunction of somatization symptoms. Key words: Somatoform disorders; Metabolic networks and pathways; Brain; Positron-emission tomography; Deoxyglucose

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体型障碍患者的脑糖代谢网络和连接性

目的观察躯体形式障碍（SFD）患者脑葡萄糖代谢网络的变化。方法18例SFD患者（男10例，女8例，年龄（39.5±12.0）岁；病程：（3.67±3.20）年）和复旦大学华山医院2011年10月至2012年12月21名匹配的健康对照（男13名，女8名，年龄：（43.9±8.4）岁），分别构建2组（SFD组、对照组）的脑葡萄糖代谢网络。然后使用图论计算全局网络属性（归一化聚类系数、归一化最短路径长度、小世界性和全局效率）和局部参数（聚类系数和节点的介数中心性）。通过1000个排列的排列检验比较两组之间的差异。根据节点的聚类系数和介数中心性结果，前20%（18/90）被归类为Hub节点。结果SFD患者的小世界性与健康对照组相似（σ>1）。SFD患者的归一化聚类系数和整体效率有降低的趋势，归一化最短路径长度有增加的趋势，但差异无统计学意义（P>0.05）。与健康对照组相比，左苍白球、左杏仁核、左楔前叶和右角回的介数中心性增加（排列检验，P<0.05）；左颞中回、右枕上回介数中心性降低（排列检验，P<0.05）；双侧苍白球、双侧丘脑和左侧杏仁核的聚类系数降低（排列检验，P<0.05），改变最多的Hub节点（16/24）属于边缘系统。结论SFD患者脑葡萄糖代谢网络拓扑性质的变化，包括小世界性和全局效率的下降趋势，以及Hub节点的改变，可能为躯体化症状的脑功能障碍提供有效的影像学证据。关键词：躯体形式障碍；代谢网络和途径；大脑；正电子发射断层扫描；脱氧葡萄糖

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来源期刊

中华核医学与分子影像杂志核医学，分子影像

自引率

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发文量

5088

期刊介绍： Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.