Association of Perfluoroalkyl Substance with Lung Function in the US Population

Brenna C. Heinle, T. Crawford, Sara J. Paton, N. Khalil
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Abstract

Background/Aim: Perfluoroalkyl substances (PFASs) are chemical compounds used in consumer products and are linked with increases in cholesterol, thyroid disease, and pregnancy-induced hypertension. However, their association with lung function is not completely understood.Methods: Cross-sectional 2011-2012 US population data from the National Health and Nutrition Examination Survey (NHANES) were analyzed (n = 1450, aged 12 to 79 years, 50.5% females). Serum concentrations of 4 PFASs, perfluoronon-anoic acid (PFNA), perfluorooctanoic acid (PFOA), perfluorooctane sulfonic acid (PFOS), and perfluorohexane sulfonic acid (PFHxS), were assessed using mass spectrometry and categorized into quartiles. Lung function was measured by spirome-try as forced vital capacity (FVC), forced expiratory volume in 1 second (FEV1), and the ratio of FEV1/FVC (%). Survey weighted sex stratified adjusted linear regression analysis was used to predict lung function with PFASs quartiles.Results: In males, compared to females, all 4 PFASs serum concentrations and lung function indices were higher, except FEV1/FVC (%) which was lower than females. No association of any PFAS with decrease in lung function was seen in multivariable-adjusted models in both males and females.Conclusion: In this exploratory analysis, PFAS exposure was not associated with lung function. PFAS contamina-tion has been ongoing for many years across the US and Ohio, and cleanup efforts are now underway. The association between PFAS exposure and lung function needs further exploration in longitudinal studies.
全氟烷基物质与美国人群肺功能的相关性
背景/目的:全氟烷基物质(PFASs)是用于消费品的化合物,与胆固醇、甲状腺疾病和妊娠高血压的增加有关。然而,它们与肺功能的关系尚不完全清楚。方法:对2011-2012年美国国家健康与营养调查(NHANES)的人口数据进行横断面分析(n = 1450,年龄12 - 79岁,50.5%为女性)。使用质谱法评估4种全氟磺酸、全氟壬酸(PFNA)、全氟辛酸(PFOA)、全氟辛烷磺酸(PFOS)和全氟己烷磺酸(PFHxS)的血清浓度,并将其分为四分位数。肺活量法测定肺功能为用力肺活量(FVC)、1秒用力呼气量(FEV1)、FEV1/FVC比值(%)。采用调查加权性别分层调整线性回归分析预测PFASs四分位数的肺功能。结果:男性4种PFASs血清浓度和肺功能指标均高于女性,但FEV1/FVC(%)低于女性。在男性和女性的多变量调整模型中,没有发现任何PFAS与肺功能下降的关联。结论:在这项探索性分析中,PFAS暴露与肺功能无关。PFAS污染在美国和俄亥俄州已经持续了多年,目前正在进行清理工作。PFAS暴露与肺功能的关系有待于进一步的纵向研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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