ACI & MACI for the Management of Osteochondritis Dissecans

IF 0.4 4区 医学 Q4 SPORT SCIENCES
Thomas Johnstone , Kevin Shea
{"title":"ACI & MACI for the Management of Osteochondritis Dissecans","authors":"Thomas Johnstone ,&nbsp;Kevin Shea","doi":"10.1016/j.otsm.2023.151008","DOIUrl":null,"url":null,"abstract":"<div><p>Osteochondritis dissecans (OCD) is defined as a focal idiopathic alteration of subchondral bone and/or its precursor with risk for instability and disruption of adjacent articular cartilage that may result in premature osteoarthritis. A robust treatment for unstable and unsalvageable OCD lesions, as well as those failing other treatments, is autologous chondrocyte implantation (ACI). In ACI procedures, a sample of healthy chondrocytes are biopsied and expanded <em>ex vivo</em> for subsequent insertion into the OCD lesion. When a biological matrix is used for chondrocyte seeding and placement rather than a periosteal flap or collagen membrane, the procedure is termed matrix-associated autologous chondrocyte implantation (MACI). This chapter aims to define the algorithm for the use of ACI and MACI in the treatment of OCD, to review available products used in ACI and MACI procedures, to discuss relevant operative techniques to implement these technologies, and to describe the reports of these methods to bolster the orthopedic surgeon's armamentarium in the fight against OCD lesions.</p></div>","PeriodicalId":54678,"journal":{"name":"Operative Techniques in Sports Medicine","volume":null,"pages":null},"PeriodicalIF":0.4000,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Operative Techniques in Sports Medicine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1060187223000345","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"SPORT SCIENCES","Score":null,"Total":0}
引用次数: 0

Abstract

Osteochondritis dissecans (OCD) is defined as a focal idiopathic alteration of subchondral bone and/or its precursor with risk for instability and disruption of adjacent articular cartilage that may result in premature osteoarthritis. A robust treatment for unstable and unsalvageable OCD lesions, as well as those failing other treatments, is autologous chondrocyte implantation (ACI). In ACI procedures, a sample of healthy chondrocytes are biopsied and expanded ex vivo for subsequent insertion into the OCD lesion. When a biological matrix is used for chondrocyte seeding and placement rather than a periosteal flap or collagen membrane, the procedure is termed matrix-associated autologous chondrocyte implantation (MACI). This chapter aims to define the algorithm for the use of ACI and MACI in the treatment of OCD, to review available products used in ACI and MACI procedures, to discuss relevant operative techniques to implement these technologies, and to describe the reports of these methods to bolster the orthopedic surgeon's armamentarium in the fight against OCD lesions.

ACI和MACI治疗夹层性骨软骨炎
夹层性骨软骨炎(OCD)被定义为软骨下骨和/或其前体的局灶性特发性改变,具有相邻关节软骨不稳定和破坏的风险,可能导致过早的骨关节炎。自体软骨细胞植入(ACI)是一种治疗不稳定和不可挽回的强迫症病变以及其他治疗失败的有效方法。在ACI过程中,健康软骨细胞样本被活检,并在体外扩增,随后插入强迫症病变。当使用生物基质而不是骨膜瓣或胶原膜进行软骨细胞播种和放置时,该过程称为基质相关自体软骨细胞植入(MACI)。本章旨在定义ACI和MACI在强迫症治疗中使用的算法,回顾ACI和MACI手术中使用的现有产品,讨论实施这些技术的相关手术技术,并描述这些方法的报告,以加强骨科医生在对抗强迫症病变方面的装备。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
求助全文
约1分钟内获得全文 求助全文
来源期刊
CiteScore
0.60
自引率
0.00%
发文量
46
审稿时长
93 days
期刊介绍: Operative Techniques in Sports Medicine combines the authority of a textbook, the usefulness of a color atlas and the timeliness of a journal. Each issue focuses on a single clinical condition, offering several different management approaches. It''s the easiest way for practitioners to stay informed of the latest surgical advancements and developments.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信