S. Joshi, A. Dhingra, B. Chopra, Kumar Guarve, Deepak K Bhateja
{"title":"Therapeutic Potential and Clinical Evidence of Hesperidin as Neuroprotective Agent.","authors":"S. Joshi, A. Dhingra, B. Chopra, Kumar Guarve, Deepak K Bhateja","doi":"10.2174/1871524922666220404164405","DOIUrl":null,"url":null,"abstract":"BACKGROUND\nNeuroprotection is preserving neural function in various neurodegenerative diseases like Alzheimer's, Huntington's, Parkinson's, and multiple sclerosis. Hesperidin, a flavanone glycoside in citrus fruits such as sweet oranges and lemons, possesses many biological effects, including neuroprotection.\n\n\nOBJECTIVE\nTo explore the neuropharmacological mechanisms and therapeutic potential of hesperidin in the management of neurodegenerative disorders.\n\n\nMETHOD\nIt emphasizes comparative and clinical trial studies with a number of targets reviewed from the data available on PubMed, Science Direct, Clinicaltrails.gov, and from many reputed foundations.\n\n\nRESULT\nEscalating clinical evidence has established the inhibitory effect of hesperidin in the management of neurodegenerative disorders. Neuroprotective potential of hesperidin is characterized through endogenous antioxidant defence functions, improvement of neural growth factors, anti-neuroinflammatory activity, and apoptotic pathways.\n\n\nCONCLUSION\nThe present study highlights the beneficial neuropharmacological potential of hesperidin including anticonvulsant, antidepressant, antioxidant, anti-inflammatory, memory, and locomotor enhancing activities.","PeriodicalId":9799,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"3","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central nervous system agents in medicinal chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871524922666220404164405","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Psychology","Score":null,"Total":0}
引用次数: 3
Abstract
BACKGROUND
Neuroprotection is preserving neural function in various neurodegenerative diseases like Alzheimer's, Huntington's, Parkinson's, and multiple sclerosis. Hesperidin, a flavanone glycoside in citrus fruits such as sweet oranges and lemons, possesses many biological effects, including neuroprotection.
OBJECTIVE
To explore the neuropharmacological mechanisms and therapeutic potential of hesperidin in the management of neurodegenerative disorders.
METHOD
It emphasizes comparative and clinical trial studies with a number of targets reviewed from the data available on PubMed, Science Direct, Clinicaltrails.gov, and from many reputed foundations.
RESULT
Escalating clinical evidence has established the inhibitory effect of hesperidin in the management of neurodegenerative disorders. Neuroprotective potential of hesperidin is characterized through endogenous antioxidant defence functions, improvement of neural growth factors, anti-neuroinflammatory activity, and apoptotic pathways.
CONCLUSION
The present study highlights the beneficial neuropharmacological potential of hesperidin including anticonvulsant, antidepressant, antioxidant, anti-inflammatory, memory, and locomotor enhancing activities.
期刊介绍:
Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.