Preliminary observation of choroidal capillary flow area and density in patients with idiopathic macular hole before and after surgery

Q4 Medicine

中华眼底病杂志 Pub Date : 2019-11-25 DOI:10.3760/CMA.J.ISSN.1005-1015.2019.06.014

X. Han, Yuhua Hao, Na-lei Zhou

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Abstract

Objective To observe the changes of choroidal capillary flow area (CBFA) and density in patients with idiopathic macular hole (IMH) before and after surgery. Methods A prospective clinical study. Thirty patients (60 eyes) with unilateral IMH diagnosed in Department of Ophthalmology of The Second Hospital of Hebei Medical University from February 2017 to March 2018 and 30 age-and sex- matched normal controls were included in this study. All eyes were divided into group A (30 affected eyes), group B (30 fellow eyes) and group C (30 normal eyes of controls). Among 30 eyes in group A, there were 5, 14, 11 eyes with hole in stage Ⅱ, Ⅲ, Ⅳ, respecitvely. The eyes in group A were divided into two subgroups according to the diameter of the holes: group D: hole diameter less than or equal to 500 μm (11 eyes), group E: hole diameter over than 500 μm (19 eyes). All eyes in group A underwent vitrectomy. Spectral-domain OCT was used to observe the diameter size of macular hole and the closure of the hole after vitrectomy in eyes of group A. The CBFA and blood flow density of superficial choroidal capillaries were measured by OCT angiography before and 3 months after vitrectomy in groups A, B and C. Univariate analysis of variance and t test were used for statistical analysis. Results Before surgery, in group A, B and C, the CBFA were 2.84±0.35, 3.19±0.23, 3.26±0.24 mm2, the blood flow density were (20.74±8.26)%, (35.18±5.20)%, (35.20±6.49)%, respectively. The CBFA and blood flow density in group A were significantly lower than those in group B and C (F=19.768, 45.583; P = 0.000, 0.000), but there was no significant difference between group B and C (F=19.768, 45.583; P=0.332, 0.994). The CBFA and blood flow density in group D were higher than those in group E (t=2.230, 2.202; P=0.034, 0.036). The diameter of macular hole was negatively correlated with CBFA and blood flow density (r=-0.377, -0.477; P=0.044, 0.009). Three months after surgery, the macular holes in group A were closed; CBFA and blood flow density in macular area were significantly higher than before surgery (t=-4.126, -4.912; P=0.000, 0.000). Conclusions CBFA and blood flow density decreased in the macular area of IMH. CBFA and blood flow density can be recovered after vitrectomy. Key words: Retinal perforations/diagnosis; Tomographyoptical coherence; Regional blood flow; Choroidal capillary flow area

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特发性黄斑裂孔患者手术前后脉络膜毛细血管流动面积及密度的初步观察

目的观察特发性黄斑裂孔（IMH）患者手术前后脉络膜毛细血管流动面积（CBFA）和密度的变化。方法前瞻性临床研究。本研究纳入了2017年2月至2018年3月在河北医科大学第二医院眼科诊断的30例（60眼）单侧IMH患者和30名年龄和性别匹配的正常对照。将所有眼睛分为A组（30只患眼）、B组（30两只同眼）和C组（30只眼正常对照眼）。A组30眼中，Ⅱ期5眼，Ⅲ期14眼，Ⅳ期11眼。A组眼睛按孔径分为两组：D组：孔径小于或等于500μm（11眼）；E组：孔径大于500μm，19眼。A组所有眼均行玻璃体切除术。采用光谱域OCT观察A组黄斑裂孔直径大小和玻璃体切除术后黄斑裂孔闭合情况。A、B、C组在玻璃体切除术前和术后3个月采用OCT血管造影术测量脉络膜浅毛细血管的CBFA和血流量密度。采用单变量方差分析和t检验进行统计分析。结果术前A、B、C组CBFA分别为2.84±0.35、3.19±0.23、3.26±0.24mm2，血流量密度分别为（20.74±8.26）%、（35.18±5.20）%和（35.20±6.49）%。A组CBFA和血流量密度显著低于B组和C组（F=19.768、45.583；P=0.000、0.000），但B组和C组之间无显著差异（F=19.76845.583；P=0.332，0.994）。D组的CBFA和血流量密度高于E组（t=2.23012.202；P=0.034，0.036）。黄斑裂孔直径与CBFA和血液流量密度呈负相关（r=-0.377，-0.477；P=0.044，0.009），A组黄斑裂孔闭合；黄斑区CBFA和血流量密度明显高于手术前（t=-4.126，-4.912；P=0.000，0.000）。玻璃体切除术后可恢复CBFA和血流量密度。关键词：视网膜穿孔/诊断；层析相干性；局部血流；弦状毛细管流动面积

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来源期刊

中华眼底病杂志 Medicine-Ophthalmology

CiteScore

0.40

自引率

0.00%

发文量

5383

期刊介绍： Chinese Journal of Ocular Fundus Diseases is the only scientific journal in my country that focuses on reporting fundus diseases. Its purpose is to combine clinical and basic research, and to give equal importance to improvement and popularization. It comprehensively reflects the leading clinical and basic research results of fundus disease disciplines in my country; cultivates professional talents in fundus disease, promotes the development of fundus disease disciplines in my country; and promotes academic exchanges on fundus disease at home and abroad. The coverage includes clinical and basic research results of posterior segment diseases such as retina, uveal tract, vitreous body, visual pathway, and internal eye diseases related to systemic diseases. The readers are medical workers and researchers related to clinical and basic research of fundus diseases. According to the journal retrieval report of the Chinese Institute of Scientific and Technological Information, the comprehensive ranking impact factor and total citation frequency of the Chinese Journal of Ocular Fundus Diseases have been among the best in the disciplines of ophthalmology, otolaryngology, and ophthalmology in my country for many years. The papers published have been included in many important databases at home and abroad, such as Scopus, Peking University Core, and China Science Citation Database (CSCD).