Effectiveness of Autologous Schwann Cell and Bone Marrow-Derived Mesenchymal Stem Cell Transplantation for Individuals With Spinal Cord Injury in Promoting Sensory Recovery

International Clinical Neuroscience Journal Pub Date : 2020-12-30 DOI:10.34172/ICNJ.2021.03

M. Golmohammadi, Mohammadhosein Akhlaghpasand, S. Oraee-Yazdani, A. Zali

{"title":"Effectiveness of Autologous Schwann Cell and Bone Marrow-Derived Mesenchymal Stem Cell Transplantation for Individuals With Spinal Cord Injury in Promoting Sensory Recovery","authors":"M. Golmohammadi, Mohammadhosein Akhlaghpasand, S. Oraee-Yazdani, A. Zali","doi":"10.34172/ICNJ.2021.03","DOIUrl":null,"url":null,"abstract":"Background: In recent decades, improvement in sensory and motor function after spinal cord injury(SCI) is a major treatment goal. Stem cell therapy has become a promising treatment strategy in theregeneration of central nervous system injuries.Methods: We assessed the effectiveness of autologous Schwann cell (SC) and bone marrow-derivedmesenchymal stem cell (MSC) for individuals with SCI in promoting sensory recovery. Five patientswith a mean ± SD age of 38.80 ± 5.84 years were enrolled in the study. The follow-up course was12 months.Results: We found sensory changes in two patients assessed by the American Spinal InjuryAssociation’s (ASIA’s) impairment scale. Systemic complications were not observed during thecourse of the study.Conclusion: There were no adverse finding after cell transplantation. Also we observed improvementin sensory score in two patients. It seems that the use of this combination of cell therapy may beeffective; but large group studies with control group are required to clarify the effect of either cells.","PeriodicalId":33222,"journal":{"name":"International Clinical Neuroscience Journal","volume":"8 1","pages":"10-13"},"PeriodicalIF":0.0000,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"International Clinical Neuroscience Journal","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.34172/ICNJ.2021.03","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}

引用次数: 0

Abstract

Background: In recent decades, improvement in sensory and motor function after spinal cord injury(SCI) is a major treatment goal. Stem cell therapy has become a promising treatment strategy in theregeneration of central nervous system injuries.Methods: We assessed the effectiveness of autologous Schwann cell (SC) and bone marrow-derivedmesenchymal stem cell (MSC) for individuals with SCI in promoting sensory recovery. Five patientswith a mean ± SD age of 38.80 ± 5.84 years were enrolled in the study. The follow-up course was12 months.Results: We found sensory changes in two patients assessed by the American Spinal InjuryAssociation’s (ASIA’s) impairment scale. Systemic complications were not observed during thecourse of the study.Conclusion: There were no adverse finding after cell transplantation. Also we observed improvementin sensory score in two patients. It seems that the use of this combination of cell therapy may beeffective; but large group studies with control group are required to clarify the effect of either cells.

查看原文本刊更多论文

自体雪旺细胞和骨髓间充质干细胞移植促进脊髓损伤患者感觉恢复的效果

背景:近几十年来，改善脊髓损伤(SCI)后的感觉和运动功能是一个主要的治疗目标。干细胞治疗已成为治疗中枢神经系统损伤再生的一种很有前途的治疗策略。方法:我们评估了自体雪旺细胞(SC)和骨髓源间充质干细胞(MSC)对脊髓损伤患者促进感觉恢复的有效性。5例患者入组，平均±SD年龄为38.80±5.84岁。随访12个月。结果:我们发现在美国脊髓损伤协会(ASIA)损伤量表评估的两名患者的感觉改变。在研究过程中未观察到全身性并发症。结论:细胞移植术后无不良反应。我们还观察到两名患者的感觉评分有所改善。似乎使用这种细胞疗法的组合可能是有效的;但需要对对照组进行大规模的研究，以阐明这两种细胞的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

International Clinical Neuroscience Journal

自引率

0.00%

发文量

审稿时长

4 weeks