Bridging the Gap between Pre-Clinical and Clinical Studies in Cancer Research

Abstract

With the advent of new technologies over the decades the field of Cancer Research has reached its pinnacle of success. Despite the success of basic and pre-clinical cancer research most of the clinical trials do not succeed with expected outcome. Basically, pre-clinical studies play an enormously important role when it comes to decide whether a drug is safe, effective, and ready for clinical trials or not. The evaluation of human specific drugs through pre-clinical studies is extremely crucial for the success of clinical trials. Unfortunately, the translatability of pre-clinical cancer research is significantly low than other therapeutic areas [1-2]. It is now a well-established fact that the clinical trials in cancer have the highest failure rate. Indeed, many significant pre-clinical findings based on which the clinical trials are designed are not actually reproducible [1]. Consequently, there is an urgent need to revisit the pre-clinical cancer research strategies to achieve a greater clinical success.