Abdominal Adipose Tissue Distribution in Male Patients with Urothelial Bladder Cancer

Abstract

Background: Adiposopathy is characterized by excessive accumulation of adipose tissue, mainly visceral, which may determine adipocyte and adipose tissue-related disorder. A connection between adipose tissue secreted factors and bladder cancer (BC) cell migration has been shown in vitro. These mediators may be related to the pathogenesis of BC. Objective: The aim of this study is to evaluate the relationship between visceral adipose tissue (VAT) and urothelial bladder cancer (UBC) in male patients. Methods: In this retrospective study two groups were included. Total adipose tissue (TAT) area, VAT area and subcutaneous adipose tissue (SAT) area were measured in both groups. VAT/SAT ratio was subsequently calculated. Results: No statistically significant differences between the two groups were found in the TAT area, VAT area, SAT area and VAT/SAT ratio. Conclusion: The results of the present study suggest that VAT is not likely to be a biomarker for UBC risk in male patients.