Symptom Severity from Posttraumatic Stress is Not Correlated to C-reactive Protein Level or Altered by Ketone Salt Supplementation

IF 0.1 Q4 MEDICINE, GENERAL & INTERNAL
Langston Gilmore, Youssef Nagy A, Jennifer Waller, R. Nalloor, Max Wieder, A. Holland-Winkler
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引用次数: 0

Abstract

This study aimed to determine if: 1) C-reactive protein (CRP) level correlated with PTSD symptom severity as measured by PTSD Checklist-5 (PCL-5), and 2) ketone supplement reduced PTSD symptoms. Twenty participants with PTSD were randomly assigned to a ketone supplementation or placebo group and evaluated for 6-weeks for PTSD symptom severity and CRP levels. The Spearman Rank correlation between PCL-5 and CRP was positive, but not statistically significant. Mixed models on the ranks of the data were used to examine the difference in PCL-5 and CRP between ketone and control groups over time. Median PCL-5 at the pre-test was higher than at the post-test in the ketone group but not in the control. The reduction of PCL-5 medians between ketone and control groups at the post-test was not different. The median pre-test CRP was not different from than post-test in the ketone group or control group. This pilot study did not find a correlation between CRP levels and PTSD symptom severity but was limited by a lack of CRP data collection due to the loss of follow-up. PTSD symptom severity was not altered by 6 weeks of chronic ketone salt supplementation compared to the control group but should be examined in a larger sample size for further verification.
创伤后应激症状的严重程度与C反应蛋白水平无关或补充酮酸盐改变
本研究旨在确定:1)c反应蛋白(CRP)水平是否与PTSD症状严重程度(PTSD Checklist-5, PCL-5)相关;2)酮类补充剂是否减轻PTSD症状。20名PTSD患者被随机分配到酮补充组或安慰剂组,并在6周内评估PTSD症状严重程度和CRP水平。PCL-5与CRP的Spearman Rank呈正相关,但无统计学意义。使用数据队列的混合模型来检查酮组和对照组之间PCL-5和CRP随时间的差异。酮组前测PCL-5中位数高于后测,对照组无此差异。酮组与对照组后测时PCL-5中位数降低无差异。酮组和对照组检测前CRP的中位数与检测后无显著差异。这项初步研究没有发现CRP水平与PTSD症状严重程度之间的相关性,但由于缺乏随访,缺乏CRP数据收集,因此受到限制。与对照组相比,6周的慢性酮盐补充没有改变PTSD症状的严重程度,但需要在更大的样本量中进行进一步的验证。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Romanian Journal of Military Medicine
Romanian Journal of Military Medicine MEDICINE, GENERAL & INTERNAL-
自引率
33.30%
发文量
2
审稿时长
12 weeks
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