Diagnostic Usefulness of Tru Cut Biopsy at a Tertiary Care Centre

Abstract

Context: Tru cut biopsy is a minimally invasive procedure because of its low morbidity and low cost and are preferred standards of care to initially access cells from tumours and other lesions for diagnostic assessment. Aims: To evaluate the usefulness of Tru cut biopsy for various tissue diagnosis and to analyse its sensitivity, specificity, positive and negative predictive values and the accuracy. Settings and Design: The present study is a prospective and retrospective observational study for patients undergoing Tru cut or excisional biopsy. Methods and Material: The present study was undertaken at the Department of Histopathology, Central Diagnostic Laboratory, Pramukhswami medical college and Shree Krishna Hospital, Karamsad, Anand for a period from April 2014 to March 2021 that included 497 samples of Tru cut biopsy. Data was retrieved from the Laboratory Information System of the hospital according to the proforma. Statistical analysis: Sensitivity, Specificity, Positive Predictive Value, Negative Predictive Value and Accuracy were found. Results: Of the 497 Tru cut biopsy samples, 105 excision biopsy were received. For the remaining 392 samples, descriptive analysis was done. Mean age of participants in excision biopsy group was 55.2±14.4 years with female participants (n=92, 87.6%) outnumbering males (n=13, 12.4%) and breast being the most common site of biopsy. There were 6 discordant and 99 concordant cases. Sensitivity, Specificity, Positive predictive value, Negative Predictive value and Accuracy were 96.73%, 92.30%, 98.8%, 80% and 96.1% respectively. Conclusions: Thus, for solitary or diffuse tissue lesions, needle biopsies provide precise localization and are much more likely to yield representative samples cost-effectively with a good safety profile. Keywords: Tru cut biopsy, Excision biopsy, Concordance, Discordance, Sensitivity