Pyrazole as an anti-microbial scaffold: A comprehensive review

Abstract

Serious and lethal infectious diseases are caused by pathogenic microorganisms. Numerous anti-microbial agents have been developed during last few decades for treating these infectious diseases, but these are still expanding worldwide over. Moreover, microorganisms are developing resistance against commercially available medicines. So, antimicrobial resistance is expanding as the most serious health threat particularly in developing countries due to easier availability of anti-microbial drugs. So, scarcity of effective antibiotics is suggesting the pressing demand of new anti-microbial agents. Modern drug discovery regarded heterocyclic compounds as its heart due to their striking structural characteristics. Pyrazole is considered as significant heterocyclic nucleus in modern drug development. This review brings a considerable summary regarding derivatives of pyrazole developed over last decade for their anti-microbial action along with docking studies carrying an expectation that it will be beneficial for medicinal chemists working in anti-microbial drug development.