Impact of iron deficiency anemia on quality of life in patients with ulcerative colitis

IF 0.3 Q4 GASTROENTEROLOGY & HEPATOLOGY
Ajay K. Jain, Sandip Vare, Shohini Sircar, Amit D. Joshi, Deepika Jain
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Abstract

Advances in the last two decades have resulted in better long-term remissions in patients with ulcerative colitis (UC), which is defined as an idiopathic, chronic inflammatory disorder of the colonic mucosa. This better remission has not transformed into a better quality of life. Almost one-third of these patients have mild to moderate anemia, which is one of the main factors leading to decreased quality of life; hence we aimed to determine the prevalence of iron deficiency anemia (IDA) in UC during remission and its impact on the quality of life in this subpopulation. In this prospective study, all consecutive patients of UC in remission for the last 3 months were evaluated for disease activity by Simple Clinical Colitis Activity Index (SCCAI), IDA by blood parameters and quality of life by Short Inflammatory Bowel Disease Questionnaire (SIBDQ). All patients with proven IDA were given oral iron supplements (Ferrous Ascorbate elemental iron 100 mg) for 3 months. Blood parameters, SCCAI, and SIBDQ scores were evaluated at the end of therapy to compare them before iron supplementation. Out of 125 patients of UC seen during the study period, 69 were in remission. IDA was seen in 34 patients (49.27%). Median pre-intervention and postintervention quality of life scores—SIBDQ (4.9 [4.2-5.8] vs 5.4 [5.0-6.1]) and blood parameters [hemoglobin 10.7 (9.8-11.4) g% vs 13.2 (12.8-13.7) g%]—showed significant improvement after iron supplementation. Prevalence of IDA in UC during remission is common (49.27%). Oral iron supplementation improves the quality of life and anemia significantly without increasing disease activity in UC under remission.

Abstract Image

缺铁性贫血对溃疡性结肠炎患者生活质量的影响
过去二十年的进展使溃疡性结肠炎(UC)患者获得了更好的长期缓解,UC被定义为结肠粘膜的特发性慢性炎症性疾病。这种更好的缓解并没有转化为更好的生活质量。这些患者中近三分之一患有轻度至中度贫血,这是导致生活质量下降的主要因素之一;因此,我们旨在确定UC缓解期缺铁性贫血(IDA)的患病率及其对该亚群生活质量的影响。在这项前瞻性研究中,通过简单临床结肠炎活动指数(SCCAI)评估过去3个月病情缓解的所有连续UC患者的疾病活动性,通过血液参数评估IDA,并通过短期炎症性肠病问卷(SIBDQ)评估生活质量。所有已证实IDA的患者均口服铁补充剂(抗坏血酸亚铁元素铁100 mg)治疗3个月。在治疗结束时评估血液参数、SCCAI和SIBDQ评分,以在补铁前进行比较。在研究期间,125名UC患者中,69人病情缓解。34名患者(49.27%)出现IDA。干预前和干预后的中位生活质量评分——SIBDQ(4.9[4.2‐5.8]vs 5.4[5.0‐6.1])和血液参数[血红蛋白10.7(9.8‐11.4)g%vs 13.2(12.8‐13.7)g%]——在补充铁后显示出显著改善。UC缓解期IDA的患病率很高(49.27%)。口服补铁可显著改善生活质量和贫血,但不会增加缓解期UC的疾病活动性。
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来源期刊
Advances in Digestive Medicine
Advances in Digestive Medicine GASTROENTEROLOGY & HEPATOLOGY-
自引率
33.30%
发文量
42
期刊介绍: Advances in Digestive Medicine is the official peer-reviewed journal of GEST, DEST and TASL. Missions of AIDM are to enhance the quality of patient care, to promote researches in gastroenterology, endoscopy and hepatology related fields, and to develop platforms for digestive science. Specific areas of interest are included, but not limited to: • Acid-related disease • Small intestinal disease • Digestive cancer • Diagnostic & therapeutic endoscopy • Enteral nutrition • Innovation in endoscopic technology • Functional GI • Hepatitis • GI images • Liver cirrhosis • Gut hormone • NASH • Helicobacter pylori • Cancer screening • IBD • Laparoscopic surgery • Infectious disease of digestive tract • Genetics and metabolic disorder • Microbiota • Regenerative medicine • Pancreaticobiliary disease • Guideline & consensus.
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