Short-term effect of deep brain stimulation on pain associated with Parkinson′s disease

Q4 Medicine

中华神经外科杂志 Pub Date : 2019-12-28 DOI:10.3760/CMA.J.ISSN.1001-2346.2019.12.006

Mengting Xu, Y. Tao, Hai⁃long Jin, S. Gong, Xingwang Yang, Xiao Sun, Yang Liu, Shimiao Wang

{"title":"Short-term effect of deep brain stimulation on pain associated with Parkinson′s disease","authors":"Mengting Xu, Y. Tao, Hai⁃long Jin, S. Gong, Xingwang Yang, Xiao Sun, Yang Liu, Shimiao Wang","doi":"10.3760/CMA.J.ISSN.1001-2346.2019.12.006","DOIUrl":null,"url":null,"abstract":"Objective \nTo investigate the short-term outcome of deep brain stimulation (DBS) for the treatment of pain associated with PD (Parkinson′s disease). \n \n \nMethods \nThe clinical data of 47 cases of PD patients with pain symptoms admitted to Neurosurgery Department of Northern Theater Command General Hospital from January 2017 to June 2018 were retrospectively analyzed. A total of 35 patients underwent STN (subthalamic nucleus)-DBS and 12 patients underwent GPi (globus pallidus internus)-DBS. The stimulation contact selection and parameter adjustment were carried out at 3 weeks post operation. Visual analogue scale (VAS) was used to evaluate the degree of preoperative and postoperative pain severity. \n \n \nResults \nThe VAS [median (upper and lower quartiles)] were 1.0 (0.5-1.4) and 1.0(0.7-1.6) respectively at 3 months and 6 months post operation in 47 patients, which was statistically different from that of pre-operation 4.0(4.0-8.0) (both P<0.001). At 3 months post operation, the improvement rate of 35 patients undergoing STN-DBS was (79.5±26.3)%, which was not statistically different from that of 12 patients undergoing GPi-DBS [(76.9±28.4)%] (P=0.78). The improvement rate of 35 patients receiving STN-DBS was (75.1±27.4)% 6 months after operation, which was not statistically different from that of 12 patients receiving GPi-DBS [(82.8±28.9)%] (P=0.86). \n \n \nConclusion \nDeep brain stimulation could effectively relieve PD-related pain. There seems no significant difference between GPi-DBS and STN-DBS in the treatment outcome of PD-related pain. \n \n \nKey words: \nParkinson disease; Pain; Deep brain stimulation; Treatment outcome","PeriodicalId":10100,"journal":{"name":"中华神经外科杂志","volume":"35 1","pages":"1216-1220"},"PeriodicalIF":0.0000,"publicationDate":"2019-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华神经外科杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.1001-2346.2019.12.006","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Medicine","Score":null,"Total":0}

引用次数: 0

Abstract

Objective To investigate the short-term outcome of deep brain stimulation (DBS) for the treatment of pain associated with PD (Parkinson′s disease). Methods The clinical data of 47 cases of PD patients with pain symptoms admitted to Neurosurgery Department of Northern Theater Command General Hospital from January 2017 to June 2018 were retrospectively analyzed. A total of 35 patients underwent STN (subthalamic nucleus)-DBS and 12 patients underwent GPi (globus pallidus internus)-DBS. The stimulation contact selection and parameter adjustment were carried out at 3 weeks post operation. Visual analogue scale (VAS) was used to evaluate the degree of preoperative and postoperative pain severity. Results The VAS [median (upper and lower quartiles)] were 1.0 (0.5-1.4) and 1.0(0.7-1.6) respectively at 3 months and 6 months post operation in 47 patients, which was statistically different from that of pre-operation 4.0(4.0-8.0) (both P<0.001). At 3 months post operation, the improvement rate of 35 patients undergoing STN-DBS was (79.5±26.3)%, which was not statistically different from that of 12 patients undergoing GPi-DBS [(76.9±28.4)%] (P=0.78). The improvement rate of 35 patients receiving STN-DBS was (75.1±27.4)% 6 months after operation, which was not statistically different from that of 12 patients receiving GPi-DBS [(82.8±28.9)%] (P=0.86). Conclusion Deep brain stimulation could effectively relieve PD-related pain. There seems no significant difference between GPi-DBS and STN-DBS in the treatment outcome of PD-related pain. Key words: Parkinson disease; Pain; Deep brain stimulation; Treatment outcome

查看原文本刊更多论文

脑深部刺激对帕金森病相关疼痛的短期影响

目的探讨脑深部电刺激(DBS)治疗帕金森病(PD)相关疼痛的近期疗效。方法回顾性分析2017年1月至2018年6月北方战区总医院神经外科收治的47例有疼痛症状的PD患者的临床资料。共有35例患者接受STN(丘脑下核)-DBS, 12例患者接受GPi(内苍白球)-DBS。术后3周进行刺激触点选择和参数调整。采用视觉模拟评分法(VAS)评价术前、术后疼痛严重程度。结果47例患者术后3个月和6个月VAS[中位数(上、下四分位数)]分别为1.0(0.5 ~ 1.4)和1.0(0.7 ~ 1.6)，与术前4.0(4.0 ~ 8.0)比较差异有统计学意义(P均<0.001)。术后3个月，35例STN-DBS患者的改善率为(79.5±26.3)%，与12例GPi-DBS患者的改善率[(76.9±28.4)%]比较，差异无统计学意义(P=0.78)。35例STN-DBS患者术后6个月的改善率为(75.1±27.4)%，与12例GPi-DBS患者的改善率[(82.8±28.9)%]差异无统计学意义(P=0.86)。结论脑深部电刺激可有效缓解pd相关性疼痛。GPi-DBS与STN-DBS对pd相关疼痛的治疗效果无显著差异。关键词:帕金森病;疼痛;脑深部电刺激;治疗结果

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

中华神经外科杂志 Medicine-Surgery

CiteScore

0.10

自引率

0.00%

发文量

10706

期刊介绍： Chinese Journal of Neurosurgery is one of the series of journals organized by the Chinese Medical Association under the supervision of the China Association for Science and Technology. The journal is aimed at neurosurgeons and related researchers, and reports on the leading scientific research results and clinical experience in the field of neurosurgery, as well as the basic theoretical research closely related to neurosurgery.Chinese Journal of Neurosurgery has been included in many famous domestic search organizations, such as China Knowledge Resources Database, China Biomedical Journal Citation Database, Chinese Biomedical Journal Literature Database, China Science Citation Database, China Biomedical Literature Database, China Science and Technology Paper Citation Statistical Analysis Database, and China Science and Technology Journal Full Text Database, Wanfang Data Database of Medical Journals, etc.