Hypoglycemic Effect Study of a Combination of Some Stipulated Spices in Alloxan Induced Diabetic Wistar Albino Rats along with Nutritional Value Evaluation

IF 1.3 4区计算机科学 Q3 COMPUTER SCIENCE, INFORMATION SYSTEMS

Journal of Database Management Pub Date : 2018-05-09 DOI:10.4236/JDM.2018.82005

Dipa Islam, Afsana Akter, A. Huque, Samina Akhter, D. Roy, C. Lyzu, M. Hakim, L. C. Mohanta, Evena Parvin Lipy, M. Siddique, K. Linkon, M. Rahman

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引用次数: 1

Abstract

The main purpose of the study was to reveal the hypoglycemic effect of a combination of some selected spices along with the evaluation of nutritional values. A sum of fourteen different types of spices at different percentages were taken into consideration to propel the research activities forward, viz; ginger, garlic, onion, red chili, turmeric, cumin, cinnamon, clove, coriander, fenugreek, black pepper, nigella, carom seed and cardamom. The healthy experimental wistar albino rats were made diabetic by injecting alloxan monohydrate intraperitoneally a dose of 150 mg/kg body weight. The rats of Group-D and Group-E were treated with the sample, mixed spices at a dose of 100 mg/kg and 200 mg/kg body weight respectively with the lab diet while in case of Group-C, glibenclamide at a dose of 0.5 mg/kg body weight was introduced with the lab diet for a total period of 21 days where as for the same days span, Group-A and Group-B were continued feeding with only lab diet. Data suggest that the mixed spices of both doses applied in Group-D and Group-E had exerted effects significantly (p < 0.05) in lowering the blood glucose level. On 22nd day, in Group-D and Group-E, the FBG level was found to be reduced by around 40.66% and 41.18% respectively compared to their respective initial days where in Group-C, the reduction was around 51.90% in comparison to its initial day. Again, in case of 2hPG level measurement, on 22nd day, both the groups, Group-D and Group-E were found with the decreased level of around 19.38% and 39.11% respectively compared to their respective initial days while the Group-C was shown with the reduced of 44.26% in comparison adopting same manner. Furthermore, various analyses confirm the presence of several micro and macro nutrients and high amount of dietary fiber in the spices mix. Thus the result affirms that this combined spice possesses strong hypoglycemic properties.

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四氧嘧啶诱导糖尿病Wistar白化大鼠配伍规定香料降血糖效果研究及营养价值评价

该研究的主要目的是揭示一些选定香料的组合的降糖效果以及营养价值的评估。总共考虑了14种不同百分比的不同类型的香料，以推动研究活动向前发展，即;姜，大蒜，洋葱，红辣椒，姜黄，孜然，肉桂，丁香，香菜，胡芦巴，黑胡椒，黑葛，豆蔻籽和小豆蔻。采用150 mg/kg体重腹腔注射一水四氧嘧啶致糖尿病的方法。d组和e组分别在实验饲粮中添加100 mg/kg和200 mg/kg体重的混合香料样品，c组在实验饲粮中添加0.5 mg/kg体重的格列苯脲，共饲喂21 d, a组和b组在相同的天数内继续只饲喂实验饲粮。数据显示，d组和e组混合香料在降低血糖水平方面均有显著作用(p < 0.05)。第22天，d组和e组的FBG水平分别比第一天降低了40.66%和41.18%左右，c组的FBG水平比第一天降低了51.90%左右。同样，在测量2hPG水平的情况下，在第22天，d组和e组的水平分别比各自的初始天下降了19.38%和39.11%左右，而c组的水平则比初始天下降了44.26%。此外，各种分析证实了香料混合物中存在几种微量和宏量营养素以及大量膳食纤维。因此，结果肯定了这种组合香料具有很强的降糖特性。

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来源期刊

Journal of Database Management 工程技术-计算机：软件工程

CiteScore

4.20

自引率

23.10%

发文量

期刊介绍： The Journal of Database Management (JDM) publishes original research on all aspects of database management, design science, systems analysis and design, and software engineering. The primary mission of JDM is to be instrumental in the improvement and development of theory and practice related to information technology, information systems, and management of knowledge resources. The journal is targeted at both academic researchers and practicing IT professionals.