Analysis of prognostic influencing factors of mixed signet ring cell carcinoma of the stomach

Q4 Medicine

肿瘤研究与临床 Pub Date : 2020-03-28 DOI:10.3760/CMA.J.CN115355-20190710-00303

Li Liu, Huiling Zhang, Guo-Feng Chen, Chunyan Wang, Hai-jiao Chen, Shanlan Guo

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引用次数: 0

Abstract

Objective To analyze the influencing factors of prognosis of early mixed signet ring cell carcinoma (SRCC) of the stomach with signet ring cell ratio less than 50%. Methods The clinical data of 110 patients with SRCC who underwent radical resection of gastric cancer in the First People's Hospital of Ziyang from January 2014 to December 2016 were retrospectively analyzed. The postoperative pathology was confirmed as mixed SRCC of the stomach with signet ring cell ratio less than 50%. The patients were followed up, and the end point of the follow-up was all-cause death. The prognostic influencing factors of SRCC patients were analyzed. Results The median follow-up time was 32.5 months (0.9-70.0 months), with the median overall survival (OS) time of 40.0 months (7.0-61.0 months) and the 3-year OS rate of 46.5%. Kaplan-Meier survival analysis showed that the 3-year OS rate of age ≥60 years, male, upper stomach, tumor diameter ≥5 cm, invasion of the gastric wall, lymph node metastasis, and vascular invasion of mixed SRCC of the stomach patients was 34.3%, 31.1%, 30.0%, 33.3%, 40.7%, 28.9%, 37.5%, respectively, which was all lower than that of those with age <60 years old, female, lower stomach, tumor diameter <5 cm, non-invasive whole stomach wall, no lymph node metastasis, no vascular invasion (57.6%, 57.5%, 52.9%, 57.6%, 56.7%, 74.6%, 62.3%), and there was no statistically significant difference (all P < 0.05). Cox multivariate results showed that age ≥60 years old (OR = 1.225, 95% CI 1.089-3.481, P = 0.003), lymph node metastasis (OR = 1.077, 95% CI 1.059-2.674, P = 0.034), invasion of the whole stomach wall (OR = 1.342, 95% CI 1.117-7.225, P = 0.002), and vascular invasion (OR = 1.104, 95% CI 1.087-2.541, P = 0.018) were independent factors affecting OS of mixed SRCC of the stomach. Conclusion Mixed SRCC of the stomach patients with signet ring cell ratio less than 50% featured by advanced age, lymph node metastasis, invasion of the full thickness of the stomach wall, and vascular invasion have a poor prognosis. Key words: Stomach neoplasms; Carcinoma, signet ring cell; Signet ring cell ratio; Prognosis

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胃混合印戒细胞癌预后影响因素分析

目的探讨影响印戒细胞比例小于50%的胃早期混合性印戒细胞癌预后的因素。术后病理证实为胃混合性小细胞癌，印戒细胞比例小于50%。对患者进行随访，随访终点为全因死亡。分析影响小细胞癌患者预后的因素。结果中位随访时间为32.5个月(0.9 ~ 70.0个月)，中位总生存期(OS)为40.0个月(7.0 ~ 61.0个月)，3年OS率为46.5%。Kaplan-Meier生存分析显示，年龄≥60岁、男性、上胃、肿瘤直径≥5 cm、侵犯胃壁、淋巴结转移、血管侵犯的胃混合型SRCC患者3年OS率分别为34.3%、31.1%、30.0%、33.3%、40.7%、28.9%、37.5%，均低于年龄<60岁、女性、下胃、肿瘤直径<5 cm、全胃壁无创、无淋巴结转移、无血管侵犯的患者(57.6%)。57.5%、52.9%、57.6%、56.7%、74.6%、62.3%)，差异无统计学意义(均P < 0.05)。Cox多因素分析结果显示，年龄≥60岁(OR = 1.225, 95% CI 1.089 ~ 3.481, P = 0.003)、淋巴结转移(OR = 1.077, 95% CI 1.059 ~ 2.674, P = 0.034)、整个胃壁侵犯(OR = 1.342, 95% CI 1.117 ~ 7.225, P = 0.002)、血管侵犯(OR = 1.104, 95% CI 1.087 ~ 2.541, P = 0.018)是影响胃混合性恶性肿瘤生存期的独立因素。结论以年龄较大、淋巴结转移、侵犯胃壁全层、血管侵犯为特征的印戒细胞比例小于50%的胃患者混合性小细胞癌预后较差。关键词:胃肿瘤;癌，印戒细胞;印戒细胞比;预后

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来源期刊

肿瘤研究与临床 Medicine-Oncology

CiteScore

0.10

自引率

0.00%

发文量

7737

期刊介绍： "Cancer Research and Clinic" is a series of magazines of the Chinese Medical Association under the supervision of the National Health Commission and sponsored by the Chinese Medical Association. It mainly reflects scientific research results and academic trends in the field of malignant tumors. The main columns include monographs, guidelines and consensus, standards and norms, treatises, short treatises, survey reports, reviews, clinical pathology (case) discussions, case reports, etc. The readers are middle- and senior-level medical staff engaged in basic research and clinical work on malignant tumors.