Effect of the Sublethal Dose of Lead Acetate on Malondialdehyde, Dopamine, and Neuroglobin Concentrations in Rats

Q4 Veterinary

World''s Veterinary Journal Pub Date : 2022-09-25 DOI:10.54203/scil.2022.wvj39

Ahmed Jasim Nawfal, B. N. Al-Okaily

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Abstract

Lead can have detrimental behavioral, biochemical, and physiological effects on the body. The current experiment was designed to estimate the sublethal dose of lead acetate that induce oxidative stress on the central nervous system (CNS) in adult using the probit analysis. Moreover, the current study examined the dose-response curve by successive doses of lead acetate on some parameters related to oxidative stress for 28 days. A total of 36 adult male rats were randomly selected and divided equally into six experimental groups and treated for 28 days. Rats in the control group received distilled sterile water, and those in G1, G2, G3, G4, and G5 were gavaged with 4, 8, 16, 32, and 64 mg/kg of lead acetate, respectively. The result indicated a positive correlation between the successive doses of lead acetate. Malondialdehyde concentration decreased dopamine and neuroglobin by increasing the dose of lead acetate in experimental groups (G3, G4, and G5), compared to the control group. In conclusion, exposure to the sublethal dose of 16 mg/kg of lead acetate significantly alters the levels of the neurotransmitters and increases the production of oxidative stress in the CNS tissue.

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亚致死剂量醋酸铅对大鼠丙二醛、多巴胺和神经球蛋白浓度的影响

铅会对人体产生有害的行为、生化和生理影响。本实验采用概率分析法估计醋酸铅诱发成人中枢神经系统氧化应激的亚致死剂量。此外，本研究还通过连续剂量醋酸铅对氧化应激相关参数进行了28天的剂量-反应曲线检测。随机选取成年雄性大鼠36只，平均分为6个实验组，治疗28 d。对照组大鼠灌胃蒸馏水，G1、G2、G3、G4、G5组大鼠分别灌胃4、8、16、32、64 mg/kg醋酸铅。结果表明，连续剂量的醋酸铅之间存在正相关关系。与对照组相比，丙二醛浓度通过增加实验组(G3、G4和G5)的醋酸铅剂量来降低多巴胺和神经球蛋白。综上所述，暴露于16 mg/kg的亚致死剂量醋酸铅显著改变了神经递质水平，增加了中枢神经系统组织氧化应激的产生。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

World''s Veterinary Journal Veterinary-Veterinary (all)

CiteScore

1.00

自引率

0.00%

发文量

期刊介绍： The World''s Veterinary Journal (ISSN 2322-4568) is an international, peer reviewed open access journal aims to publish the high quality material from veterinary scientists'' studies. All accepted articles are published Quarterly in full text on the Internet. WVJ publishes the results of original scientific researches, reviews, case reports and short communications, in all fields of veterinary science. In details, topics are: Behavior Environment and welfare Animal reproduction and production Parasitology Endocrinology Microbiology Immunology Pathology Pharmacology Epidemiology Molecular biology Immunogenetics Surgery Virology Physiology Vaccination Gynecology Exotic animals Animal diseases Radiology Ophthalmology Dermatology Chronic disease Anatomy Non-surgical pathology issues of small to large animals Cardiology and oncology.