Structure and biological functions of Helicobacter pylori lipopolysaccharide

Q4 Immunology and Microbiology

中华微生物学和免疫学杂志 Pub Date : 2019-11-30 DOI:10.3760/CMA.J.ISSN.0254-5101.2019.11.012

Tiankuo Yang, Xiaoqiong Tang, Yalin Shen, Hong Tang

{"title":"Structure and biological functions of Helicobacter pylori lipopolysaccharide","authors":"Tiankuo Yang, Xiaoqiong Tang, Yalin Shen, Hong Tang","doi":"10.3760/CMA.J.ISSN.0254-5101.2019.11.012","DOIUrl":null,"url":null,"abstract":"Helicobacter pylori (H.pylori) infection is one of the most common chronic infectious diseases in humans. It is the leading cause of chronic gastritis and peptic ulcer, and also the most important risk factor for gastric cancer. H. pylori lipopolysaccharide has unique chemical structures that are critical to the persistent infection and pathogenesis of H. pylori in human gastric mucosa. Recent studies have elucidated the H. pylori lipid A constitutive modification pathway, redefined the core-oligosaccharide and O-antigen domains, discovered that the heptan commonly present in the lipopolysaccharide structure of European strains is absent in East Asian strains and more importantly, the identification of ADP-heptose (the donor of heptose residues in lipopolysaccharide structure) as the newly discovered pathogen-associated molecular pattern, which is dependent on the type Ⅳ secretion system of H. pylori to induce inflammatory responses in host cells. This paper reviewed the resent research progress in the structure and biological functions of H. pylori lipopolysaccharide. \n \n \nKey words: \nHelicobacter pylori; Lipopolysaccharide; Heptose; ADP-heptose","PeriodicalId":10089,"journal":{"name":"中华微生物学和免疫学杂志","volume":"39 1","pages":"880-884"},"PeriodicalIF":0.0000,"publicationDate":"2019-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"中华微生物学和免疫学杂志","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.3760/CMA.J.ISSN.0254-5101.2019.11.012","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"Immunology and Microbiology","Score":null,"Total":0}

引用次数: 0

Abstract

Helicobacter pylori (H.pylori) infection is one of the most common chronic infectious diseases in humans. It is the leading cause of chronic gastritis and peptic ulcer, and also the most important risk factor for gastric cancer. H. pylori lipopolysaccharide has unique chemical structures that are critical to the persistent infection and pathogenesis of H. pylori in human gastric mucosa. Recent studies have elucidated the H. pylori lipid A constitutive modification pathway, redefined the core-oligosaccharide and O-antigen domains, discovered that the heptan commonly present in the lipopolysaccharide structure of European strains is absent in East Asian strains and more importantly, the identification of ADP-heptose (the donor of heptose residues in lipopolysaccharide structure) as the newly discovered pathogen-associated molecular pattern, which is dependent on the type Ⅳ secretion system of H. pylori to induce inflammatory responses in host cells. This paper reviewed the resent research progress in the structure and biological functions of H. pylori lipopolysaccharide. Key words: Helicobacter pylori; Lipopolysaccharide; Heptose; ADP-heptose

查看原文本刊更多论文

幽门螺杆菌脂多糖的结构与生物学功能

幽门螺杆菌(H.pylori)感染是人类最常见的慢性传染病之一。它是慢性胃炎和消化性溃疡的主要原因，也是胃癌最重要的危险因素。幽门螺杆菌脂多糖具有独特的化学结构，对幽门螺杆菌在人胃粘膜的持续感染和发病至关重要。最近的研究阐明了幽门螺杆菌脂质A的组成修饰途径，重新定义了核心寡糖和o抗原结构域，发现欧洲菌株脂多糖结构中常见的庚烷在东亚菌株中缺失，更重要的是，发现了adp -庚糖(脂多糖结构中庚糖残基的给体)是新发现的病原体相关分子模式。它依赖于幽门螺杆菌Ⅳ型分泌系统在宿主细胞中诱导炎症反应。本文综述了幽门螺杆菌脂多糖的结构和生物学功能的最新研究进展。关键词:幽门螺杆菌;脂多糖;庚糖;ADP-heptose

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

中华微生物学和免疫学杂志 Immunology and Microbiology-Virology

CiteScore

0.50

自引率

0.00%

发文量

6906

期刊介绍： Chinese Journal of Microbiology and Immunology established in 1981. It is one of the series of journal sponsored by Chinese Medical Association. The aim of this journal is to spread and exchange the scientific achievements and practical experience in order to promote the development of medical microbiology and immunology. Its main contents comprise academic thesis, brief reports, reviews, summaries, news of meetings, book reviews and trends of home and abroad in this field. The distinguishing feature of the journal is to give the priority to the reports on the research of basic theory, and take account of the reports on clinical and practical skills.