Cirsium vulgare leaves: isolation and identification of phenolic compounds

IF 0.5 4区化学 Q4 CHEMISTRY, MULTIDISCIPLINARY

Chemija Pub Date : 2021-11-09 DOI:10.6001/chemija.v32i3-4.4547

U. Griškevičienė, M. Marksa, A. Ževžikovienė, Daiva Kazlauskienė, R. Vainorienė, A. Ževžikovas, L. Ivanauskas

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引用次数: 2

Abstract

There are a few new researches on the pharmaceutical and nutraceutical application of Cirsium vulgare, but they do not reflect the full potential use of this plant. For the best of our knowledge, no study has been conducted so far to determine the impact of extraction methods and conditions on the extraction yields of phenolic compounds from Cirsium vulgare. We aimed to investigate a simple and sensitive HPLC-PDA method to determine phenolic compounds in Cirsium vulgare extracts. Three extraction techniques as maceration (ME), ultrasound-assisted extraction (UAE) and heat-reflux extraction (HRE) were applied and compared for sample preparation to obtain a high recovery of the phenolic compounds. The developed HPLC-PDA method can be used for the preparations of extracts with a high content of bioactive compounds for both pharmaceutical and nutraceutical applications. Moreover, it was validated and used for the qualitative and quantitative evaluation of phenolic compounds. A simple extraction procedure for phenolic compounds from Cirsium vulgare leaves was optimized in this work through the use of the heatreflux extraction method with 50% ethanol and extraction time of 1.5 h.

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大圆叶酚类化合物的分离鉴定

关于大圆的药用和营养应用，有一些新的研究，但并没有充分反映出大圆的潜在用途。据我们所知，到目前为止，还没有进行任何研究来确定提取方法和条件对从Cirsium vulgare中提取酚类化合物产率的影响。本研究旨在建立一种简单灵敏的HPLC-PDA法测定大蓟提取物中酚类化合物的方法。采用浸渍（ME）、超声辅助提取（UAE）和热回流提取（HRE）三种提取技术制备样品，并对其进行了比较，以获得高回收率的酚类化合物。所开发的HPLC-PDA方法可用于制备具有高含量生物活性化合物的提取物，用于药物和营养品应用。此外，它还被验证并用于酚类化合物的定性和定量评价。采用50%乙醇热回流提取法，提取时间为1.5h，优化了一种提取酸枣叶中酚类化合物的简便工艺。

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来源期刊

Chemija 化学-化学综合

CiteScore

1.30

自引率

16.70%

发文量

审稿时长

>12 weeks

期刊介绍： Chemija publishes original research articles and reviews from all branches of modern chemistry, including physical, inorganic, analytical, organic, polymer chemistry, electrochemistry, and multidisciplinary approaches.