PYGO2 (pygopus family PHD finger 2)

Abstract

PYGO2 is member of a conserved family of plant homeo domain (PHD)-containing proteins and takes part in a wide range of developmental and transcriptional processes. The most relevant role played by PYGO2 is in Wnt signaling pathway, where it is required for βcatenin/TCF-dependent transcription, even if it has showed to have a crucial role also in absence of βcatenin in tissues such as eye and testis. PYGO2 is also known as a chromatin effector because of its implication in chromatin remodelling processes through regulation of histones methylation.