ASSOCIATION BETWEEN BRCA1 POLYMORPHISMS AND BREAST CANCER IN SAARC COUNTRIES

Abstract

BRCA1 gene is highly contributed gene developing the breast cancer especially in female. Breast cancer is most prevalent cancer in South Asian Association for Regional Cooperation (SAARC) countries and risk of developing the breast cancer is now increasing rapidly. It was observed that in these countries breast cancer often develops at younger age of 30-45 years. The prevalence and the contribution of BRCA1 variations are totally different among these countries and studies. Due to the difference in genetics and epidemiology, risk factors result from ethnic differences in breast cancer. Variations of BRCA1 gene account for small study samples but the higher contributor variation of BRCA1 gene accounts with strong family history. Three BRCA1 variations (185delAG, 4184del4 and 3889delAG) are well considered in Pakistan and India. The objective of present study was to reveal the contribution of BRCA1 gene among breast cancer patients in SAARC countries. In this review, the data was collected from 8 participating SAARC countries (Pakistan, India, Sri Lanka, Bangladesh, Nepal, Maldives, Bhutan and Afghanistan). Totally 25 articles were selected from these countries. Additionally review articles were also studied for better assessment. The study presents the review on different studies of BRCA1 gene association with breast cancer.