Design and evaluation of terbutaline sulphate immediate release tablets prepared by fluidized bed granulation technology

Q3 Pharmacology, Toxicology and Pharmaceutics

Current Trends in Biotechnology and Pharmacy Pub Date : 2020-07-29 DOI:10.5530/ctbp.2020.2.16

S. Bhattacharyya, M. Rb

引用次数: 1

Abstract

Materials and methods:The process of granulation by fluidized bed granulation technology was used to prepare eight formulations (F1-F8) using various concentrations of binders PVP K30, PVP K-90 and disintegrants microcrystalline cellulose, sodium starch glycolate.The granules were evaluated for preformulation parameters like bulk density, tapped density, Carr ’s compressibility index, and hausner ratio, angle of repose, loss on drying, and sieve analysis. The compressed tablets were evaluated for post compression parameters like thickness, hardness, weight variation, friability, disintegration, drug content, content uniformity and dissolution. The stability studies were performed for a period of 3 months at 30oC/75%RH & 40oC/75%RH.

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流化床造粒法制备硫酸特布他林速释片的设计与评价

材料与方法:采用流化床造粒工艺，以不同浓度的粘结剂PVP K30、PVP K-90和崩解剂微晶纤维素、淀粉乙醇酸钠为原料，制备了8种配方(F1-F8)。评估了颗粒的预配方参数，如堆积密度，抽丝密度，卡尔压缩指数，豪斯纳比，休止角，干燥损失和筛分分析。对压片后的厚度、硬度、重量变化、脆度、崩解度、药物含量、含量均匀度、溶出度等参数进行评价。稳定性研究在30℃/75%RH和40℃/75%RH下进行了为期3个月的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Trends in Biotechnology and Pharmacy Pharmacology, Toxicology and Pharmaceutics-Pharmaceutical Science

CiteScore

0.70

自引率

0.00%

发文量

期刊介绍： The Association of Biotechnology and Pharmacy (ABAP) will be useful to form a forum for scientists so that they can bring together to discuss and find scientific solutions to the problems of society. The annual meetings will help the members to share their knowledge and publish their research knowledge particularly by members and fellows of the Association and special care will be taken to provide an opportunity for young scientists. Besides this the association is planned to organize symposia, seminars and workshops on current developments of Biotechnology and Pharmacy particularly on the subject of current scientific interest, and the proceedings of which will be published regularly. And in view of the vast development of science and to disseminate the problems in publication of research work, an international journal of Current Trends in Biotechnology and Pharmacy has been started by ABAP.