Efficacy and Safety of Trigeminal Nerve Stimulation for Migraine: A Meta-Analysis of Randomized Controlled Studies

IF 0.5 4区医学 Q4 REHABILITATION

Physikalische Medizin Rehabilitationsmedizin Kurortmedizin Pub Date : 2023-02-09 DOI:10.1055/a-2116-8022

Chunyan Deng, Yongmei Li

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引用次数: 0

Abstract

Abstract Objective Trigeminal nerve stimulation may have some potential in treating migraine, and this meta-analysis aims to study the efficacy and safety of trigeminal nerve stimulation for migraine patients. Methods We have searched several databases including PubMed, EMbase, Web of science, EBSCO and Cochrane library databases, and selected the randomized controlled trials (RCTs) comparing the efficacy of trigeminal nerve stimulation for migraine patients. This meta-analysis was conducted using the random-effect or fixed-effect model based on the heterogeneity. Results Four RCTs were included in this meta-analysis. Compared with sham procedure in migraine patients, trigeminal neurostimulation benefited to improve pain freedom at 2 h (OR=2.69; 95% CI=1.30 to 5.56; P=0.007), pain relief at 2 h (OR=2.05; 95% CI=1.53 to 2.74; P<0.00001), pain freedom at 24 h (OR=2.00; 95% CI=1.42 to 2.81; P<0.0001) as well as pain relief at 24 h (OR=1.71; 95% CI=1.25 to 2.33; P=0.0007), and reduce rescue medication (OR=0.70; 95% CI=0.52 to 0.95; P=0.02), but demonstrated no obvious impact on the incidence of adverse events (OR=2.24; 95% CI=1.21 to 4.13; P=0.01). Conclusions Trigeminal nerve stimulation is effective and safe for the treatment of migraine patients.

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三叉神经刺激治疗偏头痛的疗效和安全性：随机对照研究的Meta分析

【摘要】目的三叉神经刺激治疗偏头痛可能具有一定的治疗潜力，本荟萃分析旨在研究三叉神经刺激治疗偏头痛患者的疗效和安全性。方法检索PubMed、EMbase、Web of science、EBSCO、Cochrane等数据库，选取比较三叉神经刺激治疗偏头痛疗效的随机对照试验(rct)。本meta分析采用基于异质性的随机效应或固定效应模型。结果本meta分析共纳入4项随机对照试验。与假手术相比，三叉神经刺激有利于改善偏头痛患者2小时的疼痛缓解(OR=2.69;95% CI=1.30 ~ 5.56;P=0.007)， 2 h疼痛缓解(OR=2.05;95% CI=1.53 ~ 2.74;P<0.00001)， 24 h疼痛消失(OR=2.00;95% CI=1.42 ~ 2.81;P<0.0001)以及24小时疼痛缓解(OR=1.71;95% CI=1.25 ~ 2.33;P=0.0007)，减少抢救用药(OR=0.70;95% CI=0.52 ~ 0.95;P=0.02)，但对不良事件发生率无明显影响(OR=2.24;95% CI=1.21 ~ 4.13;P = 0.01)。结论三叉神经刺激治疗偏头痛是一种安全有效的方法。

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来源期刊

Physikalische Medizin Rehabilitationsmedizin Kurortmedizin 医学-康复医学

CiteScore

1.10

自引率

25.00%

发文量

审稿时长

3 months

期刊介绍： The Journal of Physical and Rehabilitation Medicine offers you the most up-to-date information about physical medicine in clinic and practice, as well as interdisciplinary information about rehabilitation medicine and spa medicine. Publishing 6 issues a year, the journal includes selected original research articles and reviews as well as guidelines and summaries of the latest research findings. The journal also publishes society news and editorial material. “Online first” publication ensures rapid dissemination of knowledge.