Impact of Obesity on Castelli’s Risk Index I and II, in Young Adult Females

International journal of physiology Pub Date : 2020-03-01 DOI:10.37506/IJOP.V8I1.7

D. Chandrashekhar, Anandkumar, M. Jayalakshmi, P. Babu

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引用次数: 2

Abstract

Background: Obesity is one of today’s most blatantly visible, yet most neglected, public health problems. In 2016, 39% of adults worldwide were overweight. Fueled by economic growth, urbanization, an increasingly sedentary lifestyle, and a nutritional transition to processed foods and high calorie diets over the last 30 years, many countries have witnessed the prevalence of obesity in its citizens double, and even quadruple. Obesity especially visceral obesity causes insulin resistance and is associated with dyslipidemia, impaired glucose metabolism, and hypertension all of which exacerbate atherosclerosis, and are risk factors for developing cardiovascular diseases (CVD). The primary dyslipidemia related to obesity is characterized by increased total cholesterol (TC), decreased high density lipoprotein (HDL) levels and abnormal low density lipoprotein (LDL) composition. Lipoprotein ratios are becoming increasingly popular as a way to predict atherosclerosis and CVD. Aims and Objectives: The present study was undertaken to assess the impact of overweight/obesity on lipid profile parameters and lipoprotein ratios- Castelli’s Risk Index I and II, in young adult females. Materials and Method: The present study was conducted in KIMS, Hubli, the study and its conduct was cleared by the Ethical committee. Sixty apparently healthy young females were selected for the study. Health status and other personal data were obtained via comprehensive questionnaire. The subjects were divided into two groups based on BMI; Healthy (BMI 18.5-24.99) and Overweight (BMI > 25). Lipid profile was evaluated and lipoprotein ratios calculated. Comparison between the two groups was done using students’ t-test. Results: Values for Castelli’s Risk Index I & II were found to be significantly higher in the overweight group compared to the control group. Conclusion: Obesity leads to an unfavorable lipid pattern and raises values of both Castelli’s Risk Index I & II.

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肥胖对年轻成年女性Castelli风险指数I和II的影响

背景：肥胖是当今最明显但最被忽视的公共卫生问题之一。2016年，全球39%的成年人超重。在过去30年中，在经济增长、城市化、久坐不动的生活方式以及向加工食品和高热量饮食的营养转变的推动下，许多国家的公民肥胖率翻了一番，甚至翻了四番。肥胖，尤其是内脏肥胖，会导致胰岛素抵抗，并与血脂异常、糖代谢受损和高血压有关，所有这些都会加剧动脉粥样硬化，是发展心血管疾病（CVD）的危险因素。与肥胖相关的原发性血脂异常的特征是总胆固醇（TC）升高、高密度脂蛋白（HDL）水平降低和低密度脂蛋白组成异常。脂蛋白比值作为预测动脉粥样硬化和心血管疾病的一种方法越来越受欢迎。目的和目的：本研究旨在评估超重/肥胖对年轻成年女性脂质特征参数和脂蛋白比率（Castelli风险指数I和II）的影响。材料和方法：本研究在胡布里KIMS进行，该研究及其行为已获得伦理委员会的批准。选择了60名看起来健康的年轻女性进行研究。健康状况和其他个人数据通过综合问卷获得。受试者根据BMI分为两组；健康（BMI 18.5-24.99）和超重（BMI>25）。评估脂质分布并计算脂蛋白比率。两组之间的比较采用学生t检验。结果：与对照组相比，超重组的Castelli风险指数I和II值明显更高。结论：肥胖会导致不利的脂质模式，并提高卡斯泰利风险指数I和II的值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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International journal of physiology

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