Effects of different reconstruction algorithms on SUV of pulmonary nodules in 18F-FDG PET/CT

Bin Zhao, Binwei Guo, Bin Huang, M. Liang, ZhiXing Qin, X. Hao, Sijin Li, Zhifang Wu
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引用次数: 0

Abstract

Objective To compare four reconstruction algorithms of 18F-fluorodeoxyglucose (FDG) PET/CT on standardized uptake value (SUV) of pulmonary nodules. Methods A total of 46 patients (27 males, 19 females; median age: 66 (range: 44-82) years) with solid pulmonary nodules from February 2018 to July 2019 in the First Hospital of Shanxi Medical University who performed 18F-FDG PET/CT imaging were enrolled. All PET/CT images were retrospectively reconstructed by using four algorithms reconstructions including ordered subset expectation maximization (OSEM), OSEM+ time of flight (TOF), OSEM+ TOF+ point spread function (PSF) and block sequential regularized expectation maximization (BSREM) (G1-G4). Nodule and background parameters were analyzed semi-quantitatively and visually. The maximum of SUV(SUVmax), mean of SUV(SUVmean) and peak of SUV (SUVpeak) were collected by the region of interest (ROI). Nodules were divided into small nodule group (diameter ≤10 mm) and large nodule group (10 mm < diameter ≤30 mm). Kruskal-Wallis rank sum test and Bonferroni method were performed to compare the differences of SUVs between G1-G4, and Spearman correlation analysis was used to analyze the correlation between the change rate of SUV (%ΔSUV) and the diameter of nodules. The receiver operating characteristic (ROC) curve analysis was used to analyze the diagnostic efficacy of SUV for the differential diagnosis of pulmonary nodules and to get the optimal threshold. Results There were 114 pulmonary nodules (large nodules, n=55; small nodules, n=59). In visual analysis, the visual detection rates of small nodules in G4 were 55.93%(33/59), 44.07%(26/59), 20.34%(12/59) higher than those in G1-G3. Of 114 pulmonary nodules in 46 patients, there were differences in SUVmax and SUVmean between G1-G4 (median SUVmax : 2.65-5.29, median SUVmean: 2.05-2.99; H values: 20.628 and 17.749, respectively, both P 0.05). The optimal threshold values of SUVmax in G1-G4 were 4.335, 5.185, 5.410, 5.745 and the area of under curves (AUCs) were 0.747, 0.699, 0.756, 0.778 respectively. The AUC of SUVmean and SUVpeak also showed a similar trend. Conclusion Among the four reconstruction algorithms, BRERM can not only enhance the image quality, but also significantly improve the SUVmax and SUVmean of lung nodules diameter below 10 mm, and thus its diagnostic threshold of SUV should be appropriately increased. Key words: Lung neoplasms; Positron-emission tomography; Tomography, X-ray computed; Image processing, computer-assisted; Deoxyglucose
不同重建算法对18F-FDG PET/CT肺结节SUV的影响
目的比较4种18f -氟脱氧葡萄糖(FDG) PET/CT对肺结节标准化摄取值(SUV)的重建算法。方法共46例患者,其中男27例,女19例;纳入2018年2月至2019年7月在山西医科大学第一医院行18F-FDG PET/CT成像的实性肺结节患者,中位年龄:66岁(范围:44-82岁)。采用有序子集期望最大化(OSEM)、OSEM+飞行时间(TOF)、OSEM+ TOF+点扩散函数(PSF)和块顺序正则化期望最大化(BSREM) (G1-G4) 4种算法对所有PET/CT图像进行回顾性重构。对结节和背景参数进行半定量和可视化分析。通过感兴趣区域(ROI)收集SUV的最大值(SUVmax)、平均值(SUVmean)和峰值(SUVpeak)。将结节分为小结节组(直径≤10 mm)和大结节组(直径≤10 mm)。采用Kruskal-Wallis秩和检验和Bonferroni法比较G1-G4间SUV的差异,采用Spearman相关分析分析SUV变化率(%ΔSUV)与结节直径的相关性。采用受试者工作特征(ROC)曲线分析SUV对肺结节鉴别诊断的诊断效果,得出最佳阈值。结果114例肺结节(大结节55例;小结节,n=59)。视觉分析中,G4小结节的视觉检出率分别比G1-G3高55.93%(33/59)、44.07%(26/59)、20.34%(12/59)。46例肺结节114例,G1-G4间SUVmax和SUVmean有差异(中位SUVmax: 2.65-5.29,中位SUVmean: 2.05-2.99;H值分别为20.628和17.749,P均为0.05)。g1 ~ g4的SUVmax最优阈值分别为4.335、5.185、5.410、5.745,下曲线面积(aus)分别为0.747、0.699、0.756、0.778。SUVmean和SUVpeak的AUC也呈现出类似的趋势。结论在四种重建算法中,BRERM不仅能增强图像质量,而且能显著提高直径小于10 mm肺结节的SUVmax和SUVmean,应适当提高其对SUV的诊断阈值。关键词:肺肿瘤;正电子发射断层扫描;断层扫描,x射线计算机;图像处理,计算机辅助;脱氧葡萄糖
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来源期刊
中华核医学与分子影像杂志
中华核医学与分子影像杂志 核医学,分子影像
自引率
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发文量
5088
期刊介绍: Chinese Journal of Nuclear Medicine and Molecular Imaging (CJNMMI) was established in 1981, with the name of Chinese Journal of Nuclear Medicine, and renamed in 2012. As the specialized periodical in the domain of nuclear medicine in China, the aim of Chinese Journal of Nuclear Medicine and Molecular Imaging is to develop nuclear medicine sciences, push forward nuclear medicine education and basic construction, foster qualified personnel training and academic exchanges, and popularize related knowledge and raising public awareness. Topics of interest for Chinese Journal of Nuclear Medicine and Molecular Imaging include: -Research and commentary on nuclear medicine and molecular imaging with significant implications for disease diagnosis and treatment -Investigative studies of heart, brain imaging and tumor positioning -Perspectives and reviews on research topics that discuss the implications of findings from the basic science and clinical practice of nuclear medicine and molecular imaging - Nuclear medicine education and personnel training - Topics of interest for nuclear medicine and molecular imaging include subject coverage diseases such as cardiovascular diseases, cancer, Alzheimer’s disease, and Parkinson’s disease, and also radionuclide therapy, radiomics, molecular probes and related translational research.
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