Importance of screening in the prevention of emergence and spread of MDR bacteria

Q4 Medicine
F. Numanović, J. Smajlović, Elsada Čičko, Z. Delibegović, Merima Gegić, Hanka Kikanović, A. Bećirović, E. Halilović, Mubera Kutlovac, Indira Džanić
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Abstract

Background: Colonization is the presence of bacteria in the intestines, skin, nose, throat or anywhere in the human body without any signs of infection but with increased risk for spreading bacteria to other patients and the emergence of new infections. Screening of colonized patients is used as part of the prevention and control of multidrug-resistant (MDR) infections caused by agents such as methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecalis and multi-resistant Gram-negative bacteria. Material and methods: Data from 169 screened respondents hospitalized at the University Clinical Center Tuzla, between October 1, 2018, and May 1, 2019, were analyzed. Swabs were taken from nostrils, throat, axilla and groin area for all patients, and also from the anorectal area for 157 of them. Identification of MDR bacteria was done by phenotypical methods, according to the recommendations of EUCAST Clinical Breakpoint Table v.8.0, 2018. Results: Out of 169 patients, negative screening test results were found in 93 examinees (55.02%), and positive in 76 (44.97%). The largest number of patients undergoing screening was hospitalized in the Intensive Care Unit (Surgical Block), 73/169 (43.19%). The average screening time was 2.2 days or 53 hours. In 18/76 (23.68%) of patients with positive screening, prior to screening regular microbiological testing was done, and in the remaining 58/76 (76.3%) screening was performed first. Analyzing respondents with positive screening, 27 (35.53%) had negative findings during regular microbiological testing of different biological samples and for 49 (64.47%) different/same strains of MDR bacteria were isolated.Conclusion: Knowing the phenotypic profile of bacteria colonizing patients in intensive care units is a very useful tool in preventing their spread intra- and inter-hospitals.
筛查在预防耐多药细菌出现和传播中的重要性
背景:定植是指细菌在肠道、皮肤、鼻子、喉咙或人体任何地方存在,没有任何感染迹象,但增加了将细菌传播给其他患者和出现新感染的风险。定植患者的筛查是预防和控制多重耐药(MDR)感染的一部分,这些感染是由耐甲氧西林金黄色葡萄球菌、耐万古霉素粪肠球菌和多重耐药革兰氏阴性细菌等病原体引起的。材料和方法:分析2018年10月1日至2019年5月1日期间在图兹拉大学临床中心住院的169名筛选受访者的数据。所有患者均从鼻孔、咽喉、腋窝和腹股沟区采集拭子,其中157例患者也从肛门直肠区采集拭子。根据EUCAST临床断点表v.8.0, 2018的建议,采用表型法对MDR细菌进行鉴定。结果:169例患者中筛查试验阴性93例(55.02%),阳性76例(44.97%)。接受筛查的患者中,在重症监护病房(外科区)住院的患者最多,为73/169(43.19%)。平均筛查时间为2.2天或53小时。筛查阳性患者中18/76(23.68%)在筛查前进行常规微生物学检测,其余58/76(76.3%)先进行筛查。对筛查阳性的应答者进行分析,27例(35.53%)在不同生物样本的常规微生物学检测中发现阴性,49例(64.47%)分离到不同/相同菌株的耐多药细菌。结论:了解重症监护病房患者定植细菌的表型特征是预防其在医院内和医院间传播的重要手段。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Acta Medica Saliniana
Acta Medica Saliniana Medicine-Medicine (all)
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