Profile of Candida Resistancy to Fluconazole in Male Patient with Oral Candidiasis and HIV/AIDS

Abstract

Background: Oral candidiasis is one of the most common opportunistic infections found in patients with Human Immunodeficiency Virus (HIV)/Acquired immune deficiency syndrome (AIDS). The number of HIV/AIDS patient increases every years. Past studies revelead the increment in the resistance of Candida species causing oral candidiasis against Fluconazole despite Fluconazole being the treatment of choice for this condition. Objective: To evaluate the resistancy of Candida species to fluconazole in male patients with oral candidiasis and HIV/AIDS. Methods: This was a descriptive observational study conducted in Dr. Soetomo General Hospital, Surabaya. The candida species was identified by using conventional methods. Resistancy against fluconazole were evaluated bydiskdiffusion method. Results: There were 20 research subjects with 37 isolates of Candida species growing in culture. Candida species was found in 20 (54.1%) isolates, while 17 (45.9%) isolates showed non-albicans species. The resistance test of Candida species to fluconazole revealed that 18 (48.6%) isolates were resistant to fluconazole. Majority of the resistant isolates were of Candida non-albicans 13 isolates (72.2%). Conclusion: The use of fluconazole drugs especially in patients with HIV/AIDS should be reevaluated as Candida species has developed high resistance towards the medication.