Evaluating laboratory screening tests for malaria on blood donors candidates to reduce the risk of transfusion-transmitted malaria in an endemic area of Indonesia

IF 0.5 Q3 MEDICINE, GENERAL & INTERNAL
Nethasia Louhenapessy, Ria Syafitri Evi Gantini, Susan Rahayu, Elisabeth Lilipory, Heri Wibowo, Yuyun Soedarmono, Inge Sutanto
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Abstract

BACKGROUND Laboratory screening of blood donors for malaria has not been routinely performed in Indonesia. Current policy and practice simply exclude donors based on a history of active clinical malaria. This study was aimed to evaluate laboratory screening tests for malaria among blood donors in an endemic area of Indonesia. METHODS The study was conducted on 550 consecutive blood samples withdrawn from volunteer donors at the Red Cross Blood Transfusion Unit in Ambon city using microscopic and rapid diagnostic tests for antigen as well as for antibody. Furthermore, 248 of those 550 samples were also tested for the presence of malaria DNA using 18S rRNA marker. Statistical analysis was done descriptively using SPSS software version 15 (SPSS Inc., USA). RESULTS The overall malaria positivity rate among the donors was 4.5% (25/550). None of the specimens tested using microscopy or rapid test for malaria antigen assay were positive. However 22 (4.0%) samples were positive for malaria antibody against Plasmodium falciparum; while 3 (1.2%) were positive by PCR. CONCLUSIONS Laboratory testing for blood donors may be used to prevent transfusiontransmitted malaria in an endemic area of Indonesia.
评估对献血者候选人进行的疟疾实验室筛查试验,以减少印度尼西亚一个流行地区输血传播疟疾的风险
背景:在印度尼西亚,对献血者进行疟疾实验室筛查尚未成为常规做法。目前的政策和做法只是简单地根据临床疟疾活跃史排除捐助者。本研究的目的是评价印度尼西亚一个疟疾流行地区献血者的疟疾实验室筛查试验。方法对安汶市红十字会输血中心志愿献血者的550份连续血液样本进行研究,采用抗原和抗体的显微镜和快速诊断检测。此外,还使用18S rRNA标记对这550个样本中的248个样本进行了疟疾DNA检测。统计分析使用SPSS软件版本15 (SPSS Inc., USA)进行描述性分析。结果供体疟疾总阳性率为4.5%(25/550)。使用显微镜或疟疾抗原测定快速试验检测的标本均未呈阳性。恶性疟原虫疟疾抗体阳性22份(4.0%);PCR阳性3例(1.2%)。结论对献血者的实验室检测可用于预防印度尼西亚某流行地区的输血传播性疟疾。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Medical Journal of Indonesia
Medical Journal of Indonesia MEDICINE, GENERAL & INTERNAL-
CiteScore
1.00
自引率
20.00%
发文量
25
审稿时长
24 weeks
期刊介绍: Medical Journal of Indonesia is a peer-reviewed and open access journal that focuses on promoting medical sciences generated from basic sciences, clinical, and community or public health research to integrate researches in all aspects of human health. This journal publishes original articles, reviews, and also interesting case reports. Brief communications containing short features of medicine, latest developments in diagnostic procedures, treatment, or other health issues that is important for the development of health care system are also acceptable. Letters and commentaries of our published articles are welcome.
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