Estimation of Some Mineral (Calcium, Phosphorous, Vitamin 25(OH) D, And Alkaline Phosphatase) in Osteoporosis Patients In Kirkuk City

Abstract

Introduction: Osteoporosis is a growing public health problem of the elderly; it’s qualified by low bone mineral density (BMD), with its associated increased risk of fractures. Despite the intensive researches, there are still large areas to explore with regard to its etiology. Method and subject: We enrolled 100 female patients (40-80 years) in this study who attended the rheumatology Unit at Azadi teaching hospital/ Kirkuk city from February 2015 to July 2016 50 patents had osteoporosis confirmed by DEXA scan and the remaining ones who are age matched were controls. We measured Vitamin D, Calcium, and Phosphorus and Alkaline phosphatase in the sera of the entire participant. A special questionnaire form was arranged and full information were collected from each subject include: name, age, sex, patients’ weight and height were measured. Result: One hundred women were enrolled in this study with mean age of (61.0 ± 10.2) years were studied; 50% of them were controls and 50% of them had osteoporosis. Age of osteoporosis group were significantly higher than control groups (56 ± 9.0) years also BMI significantly higher (p<0.001) in osteoporosis (29.1 ± 5.9) compared to the control group (28.9 ± 3.4). Both control and osteoporosis cases had calcium and phosphorus within normal range, however the difference between the levels was significantly higher in osteoporotic (8.89 ± 0.564) mg/dl than control groups (8.776 ± 0.496) mg/dl. Serum alkaline phosphatase was significantly higher in osteoporosis (96.89 ± 8.00) in comparison to the control group (81.0 ± 12.4) yet their values are still within normal range. Interestingly the vitamin D deficiency was prevalent in the study population; it was significantly much lower in the osteoporosis group compared to the control group. According to chi-square test the age significantly associated with BMD, vitamin D, and phosphor in osteoporosis groups while in the control group the age was strongly associated with BMD only. The study showed correlation between Vitamin D and Bone mineral density. Conclusion: We conclude that there was no significant association between serum Calcium, Phosphors, and alkaline phosphates with bone mineral density while show positive association between age and vitamin 25 (OH) D levels.