Role of ‘C’ Reactive Protein, Haemoglobin, Red Blood Cell, White Blood Cell and Platelet in Sickle Cell Disease Patients of Tribal District.

Abstract

Sickle cell gene is widespread among many tribal and other general population groups in India. This disorderis recessive in nature. The heterozygous [HbAS] are absolutely asymptomatic but the homozygous [HbSS]suffer from serious complications leading to short life span. This may be due to vaso-occlusive crisis whichoccurs in HbSS patient. The present study aimed to assess the importance of CRP, WBC count, Haemoglobin,RBC and platelet count in sickle cell disease patient, measurement of these lifesaving parameters shouldbe done as routine follow up for patient with sickle cell disease to increase awareness among these patient.About 30 sickle cell patient attending sickle cell OPD run by pathology department at Shri Vasantrao NaikGovt Medical College Yavatmal are taken for the present study, their average age was 12 to 50 years. Anydiagnosed case of sickle cell disease having CBC and HPLC already done and presenting in painful crisiswere approached with a request to participate in our study. Less than 5 ml of blood is withdrawn from cubitalvein of sickle cell patient in a plane bulb for CRP estimation. In this test highest dilution of serum showingagglutination 0.6 ml/dl is taken as highly sensitiveComparison of above parameters in CRP positive and CRP negative HbSS and HbAS patients shows that thevalues of haemoglobin, RBC, WBC and Platelet are highly significant in CRP+ve HBSS patient as compareto CRP-ve HBAS pt.