Postprandial Dysmetabolism (Postprandial Hyperglycemia and Hypertriglyceridemia) in Type 2 Diabetes Patients

Abstract

Postprandial dysmetabolism [postprandial hyperglycemia (PPG) and postprandial hypertriglyceridemia (PPTG)] was used as acardiovascular disease (CVD) risk factor and as the biomarker for carbohydrates and lipids homeostasis assessment. Postprandial dysmetabolism is an underlying riskin type 2 diabetesmellitus (T2DM) patients even their have good control fasting glucose (FGlu) and triglyceride (FTG) levels. We tried to evaluate the postprandial dysmetabolismin T2DM patients. Twenty fiveT2DM patients, who reached the criteriavolunteered to participate and answered the questionnaires in the present study. Anthropometric and blood pressure (BP) were measured. All patients were received their regular medication. Fasting blood samples were collected for plasma Glu, total cholesterol (TC) and TGanalysis as in Fasting (F) condition.After that all patients received a conventional meal type as their lifestyle in everydaywith a duration time about 10-15 min. Then, blood samples were drawn after 2 hour of this meal load as Postprandialcondition. These patients were older, obesewith good control on FGlu and FTG levels and demonstrated PPG with 41.83% Glu retention and PPTG with 17.30% TG retention after 2 hours of meal load. There is no significant change in FTC and PPTC levels. FGlu, FTC, FTG, PPG and PPTG were significantly correlated with PPG, PPTC, PPTG, % Glu retention and %TG retention. Conclusion, postprandial dysmetabolism is the good biomarker for CVD risk factor and the carbohydrates and lipids homeostasis assessment after meal load, especially in T2DM and obese patient even their apparently good Glu and TG control.