Effectiveness of Xuebijing injection for sepsis: an overview of systematic reviews and meta-analyses

Abstract

© Longhua Chinese Medicine. All rights reserved. Longhua Chin Med 2021 | https://dx.doi.org/10.21037/lcm-21-13 Sepsis is a devastating condition caused by dysregulated host response to infection which leads to organ failure and death (1). In 2017, an estimated 49 million incident cases of sepsis were recorded worldwide among which more than 40% were children younger than 5 years, and 11 million sepsis-related deaths were reported, representing about 1/5 of all global deaths (2). Sepsis not only imposes a high burden on hospitalized patients (3), but also affects their quality of life, because half of the discharged patients are still not completely recovered (4,5). It has become a global public health concern due to its high mortality and morbidity and substantial economic burden (6). Moreover, with aging of the population, the presence of more people suffering from chronic diseases or on immunosuppressive medications, and the increase in invasive procedures, the incidence of sepsis will continue to increase (7,8). Review Article