Emulgel: An Emerging Approach towards Effective Topical Drug Delivery

Q2 Pharmacology, Toxicology and Pharmaceutics

Drug Delivery Letters Pub Date : 2022-08-18 DOI:10.2174/2210303112666220818115231

P. Pandey, N. Minocha, N. Vashist, Rashmi Shah, Sapna Saini, Manish Makhija, Deepika Purohit, D. Kaushik

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引用次数: 2

Abstract

During the development of the new formulations, the hydrophobic drugs face many problems leading to poor water solubility and problems related to bioavailability. Topical drug delivery is a popular and unique process that directs the action of various drugs on the skin for the treatment and diagnosis of various diseases and disorders such as urticaria, inflammation, rheumatism, etc. This topical release system is usually used to escape the first-pass metabolism. An emulgel is a superior formulation with combined advantages of both an emulsion and agel. Gel preparations normally offer earlier drug release than other predictable ointments and creams. The main aim of this review is to deal with the problems associated with the delivery of hydrophobic drugs and to tackle these problems using an emulgel formulation. Emulgel mainly provides better stability, prolonged local contact, controlled release of drugs with short half-life, and better loading capacity. The review was extracted from the searches performed in PubMed, Google Patents, Medline, and Google Scholars, etc. Data from these searches were collected and evaluated to get information about the available literature on the emulgel formulation. The literature obtained was studied thoroughly as per the requirement of the objective of this review. The details of the emulgel formulation, the advantages and disadvantages associated with it, and the methods for characterization of the formulation are compiled here in this review. Along with this, some reported patents have also been included in this review to conclude the future of emulgel formulation in topical drug delivery. Emulgel is becoming very popular as a drug delivery system to deliver many antifungal, analgesics, anti-acne, anti-inflammatory drugs, and a number of cosmetics with a wide scope to be explored further. This review article is motivated by the formulation, characterization, patents, and biological activities of emulgel formulation.

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乳凝胶:一种有效的局部药物递送的新方法

在新配方的开发过程中，疏水药物面临着水溶性差和生物利用度等问题。局部给药是一种流行而独特的过程，它指导各种药物在皮肤上的作用，以治疗和诊断各种疾病和失调，如荨麻疹、炎症、风湿病等。这种局部释放系统通常用于逃避第一次代谢。无乳凝胶是一种优越的配方，结合了乳液和凝胶的优点。凝胶制剂通常比其他可预测的软膏和乳膏提供更早的药物释放。本综述的主要目的是处理与疏水药物递送相关的问题，并利用凝胶制剂解决这些问题。乳凝胶主要具有稳定性好、局部接触时间长、半衰期短、药物控释、载药能力强等特点。这篇综述摘自PubMed、谷歌Patents、Medline和谷歌Scholars等网站的搜索结果。从这些搜索的数据被收集和评估，以获得有关乳凝胶配方的可用文献信息。根据本综述目的的要求，对所获得的文献进行了彻底的研究。本综述将详细介绍乳液配方、其优缺点以及表征该配方的方法。与此同时，本综述也包括了一些已报道的专利，以总结凝胶制剂在局部给药中的未来。乳凝胶作为一种药物输送系统正变得非常流行，可以输送许多抗真菌、镇痛药、抗痤疮、抗炎药和许多化妆品，其应用范围还有待进一步探索。本文综述了乳凝胶制剂的配方、特性、专利和生物活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Drug Delivery Letters Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

CiteScore

1.70

自引率

0.00%

发文量