SIARD model and effect of lockdown on the dynamics of COVID-19 disease with non total immunity

IF 2.6 4区 数学 Q2 MATHEMATICAL & COMPUTATIONAL BIOLOGY
M. Aziz-Alaoui, F. Najm, R. Yafia
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引用次数: 5

Abstract

We propose a new compartmental mathematical model describing the transmission and the spreading of COVID-19 epidemic with a special focus on the non-total immunity. The model (called SIARD) is given by a system of differential equations which model the interactions between five populations “susceptible”, “reported infectious”, “unreported infectious”, “recovered with/without non total immunity” and “death”. Depending on the basic reproduction number, we prove that the total immunity induces local stability-instability of equilibria and the epidemic may disappear after a first epidemic wave and more epidemic waves may appear in the case of non-total immunity. Using the sensitivity analysis we identify the most sensitive parameters. Numerical simulations are carried out to illustrate our theoretical results. As an application, we found that our model fits well the Moroccan epidemic wave, and predicts more than one wave for French case.
SIARD模型及封锁对非完全免疫COVID-19疾病动力学的影响
我们提出了一个新的分区数学模型来描述COVID-19流行病的传播和传播,并特别关注非完全免疫。该模型(称为SIARD)由一个微分方程系统给出,该系统模拟了"易感"、"报告感染"、"未报告感染"、"有/没有非完全免疫恢复"和"死亡"五个群体之间的相互作用。根据基本繁殖数,我们证明了总免疫引起平衡点的局部稳定-不稳定,并且在非总免疫的情况下,在第一波流行后流行病可能消失,并且可能出现更多的流行波。通过灵敏度分析,确定了最敏感的参数。数值模拟验证了理论结果。作为应用,我们发现我们的模型很好地拟合了摩洛哥的流行波,并预测了法国病例的多个流行波。
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来源期刊
Mathematical Modelling of Natural Phenomena
Mathematical Modelling of Natural Phenomena MATHEMATICAL & COMPUTATIONAL BIOLOGY-MATHEMATICS, INTERDISCIPLINARY APPLICATIONS
CiteScore
5.20
自引率
0.00%
发文量
46
审稿时长
6-12 weeks
期刊介绍: The Mathematical Modelling of Natural Phenomena (MMNP) is an international research journal, which publishes top-level original and review papers, short communications and proceedings on mathematical modelling in biology, medicine, chemistry, physics, and other areas. The scope of the journal is devoted to mathematical modelling with sufficiently advanced model, and the works studying mainly the existence and stability of stationary points of ODE systems are not considered. The scope of the journal also includes applied mathematics and mathematical analysis in the context of its applications to the real world problems. The journal is essentially functioning on the basis of topical issues representing active areas of research. Each topical issue has its own editorial board. The authors are invited to submit papers to the announced issues or to suggest new issues. Journal publishes research articles and reviews within the whole field of mathematical modelling, and it will continue to provide information on the latest trends and developments in this ever-expanding subject.
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