Association between Mediterranean diet and Parkinson’s disease in adults: A systematic review and meta-analysis of cohort studies

IF 0.7 Q4 NUTRITION & DIETETICS

Mediterranean Journal of Nutrition and Metabolism Pub Date : 2022-01-18 DOI:10.3233/mnm-210019

M. Keramati, Vali Musazadeh, S. Kheirouri

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引用次数: 0

Abstract

BACKGROUND: Parkinson’s disease (PD) is a chronic neurodegenerative disorder, and previous studies have shown that the Mediterranean diet (MeDi) can be effective in reducing the incidence and progression of the disease. OBJECTIVE: The purpose of this study was to determine an association between adherence to MeDi and the risk of PD in adults by meta-analysis of cohort studies. METHODS: Online databases including Scopus, PubMed, Web of Science, and Google Scholar were searched up to March 2021. Cohort studies that examined the association of PD risk with adherence to MeDi were included. A pooled relative risk with a 95% confidence interval was calculated by a random effects meta-analysis. As well, bias assessment, assessment of heterogeneity, sensitivity, and subgroup analyses were carried out. The primary outcome was Parkinson’s incidence. RESULTS: Overall four papers on PD risk were included in the present systematic review and meta-analysis. The effect size of the summary for the risk of overall PD, comparing the highest with the lowest adherence to MeDi, was 0.76 (95% CI: 0.59, 0.98), indicating a significant inverse association. CONCLUSIONS: Adherence to MeDi has a protective role against PD. Also, adhering to this dietary pattern at a younger age may be more beneficial in reducing the risk of PD. However, we suggest more prospective cohort studies in this regard.

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地中海饮食与成人帕金森病之间的关系:队列研究的系统回顾和荟萃分析

背景:帕金森病(PD)是一种慢性神经退行性疾病，既往研究表明地中海饮食(MeDi)可有效降低该病的发病率和进展。目的:本研究的目的是通过队列研究的荟萃分析，确定成人坚持服用MeDi与PD风险之间的关系。方法:检索截止到2021年3月的在线数据库，包括Scopus、PubMed、Web of Science和b谷歌Scholar。纳入了检查PD风险与坚持使用medii相关的队列研究。通过随机效应荟萃分析计算出95%置信区间的综合相对风险。此外，还进行了偏倚评估、异质性评估、敏感性评估和亚组分析。主要终点是帕金森病的发病率。结果:本系统综述和荟萃分析共纳入了4篇关于帕金森病风险的论文。总体PD风险的总结效应大小，比较最高和最低依从MeDi，为0.76 (95% CI: 0.59, 0.98)，表明显著负相关。结论:坚持服用medii对帕金森病具有保护作用。此外，在年轻时坚持这种饮食模式可能对降低帕金森病的风险更有益。然而，我们建议在这方面进行更多的前瞻性队列研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mediterranean Journal of Nutrition and Metabolism NUTRITION & DIETETICS-

CiteScore

1.70

自引率

9.10%

发文量

期刊介绍： The Mediterranean Journal of Nutrition and Metabolism publishes original scientific papers on metabolism, including diabesity and eating disorders; nutrition (epidemiological, basic, clinical and artificial); dietary and nutritional practices and management and their impact on health from prevention to treatment. The journal hosts the proceedings of relevant congresses and presents shorter notices focused on the original character of the Mediterranean nutritional civilisation. In addition, this journal is intended as a platform for scientific debate and knowledge-sharing among students and clinical practitioners, and between them and the broader scientific community, and finally as a tool for promoting and enhancing scientific cooperation.