A New Monoterpene Rhamnoside from Cercis glabra Legumes

IF 1.5 4区生物学 Q3 CHEMISTRY, APPLIED

Records of Natural Products Pub Date : 2022-10-27 DOI:10.25135/rnp.362.2209.2593

Penghua Shu, Tingxiao Xu, Yueyue Lou, Yabing Ge, Xiaoqing Lu, Pengpai Zhang

引用次数: 0

Abstract

: A new monoterpene rhamnoside, (+)-( R )- α -terpineol α -L-rhamnoside ( 1 ), along with ten known compounds ( 2 – 11 ) were obtained after purification of the ethanol extract of Cercis glabra legumes. Their structures were elucidated by spectroscopic evidence including NMR, optical rotatory dispersion (ORD), HR-ESI-MS and chemical hydrolysis. In the acetylcholinesterase inhibitory assay, compounds 3 and 8 showed high percentages of inhibition which were comparable to the activity of donepezil (a commercial drug, the positive control), and exhibited IC 50 values of 0.488, 0.391 mg/mL. These bioactive components could be promising acetylcholinesterase inhibitors.

查看原文本刊更多论文

一种新的单萜类鼠李糖苷

：经过对光叶Cercis豆科植物乙醇提取物的纯化，获得了一种新的单萜鼠李糖苷，（+）-（R）-α-萜品醇α-L-鼠李糖苷（1）和10种已知化合物（2-11）。通过核磁共振、旋光分散（ORD）、HR-ESI-MS和化学水解等光谱证据对它们的结构进行了鉴定。在乙酰胆碱酯酶抑制测定中，化合物3和8显示出高百分比的抑制作用，其与多奈哌齐（商业药物，阳性对照）的活性相当，并且表现出0.488、0.391mg/mL的IC50值。这些生物活性成分可能是很有前途的乙酰胆碱酯酶抑制剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Records of Natural Products 生物-医药化学

CiteScore

3.10

自引率

26.30%

发文量

审稿时长

4 months

期刊介绍： Records of Natural Products is a journal of natural product chemistry. Reviews, book reviews, research papers and short reports are considered on the substances of plants, microbes and animals. Discussions on the structure elucidation, synthesis of naturally occurring compounds and biological activity of natural compounds and plant extracts, biosynthesis of natural products and essential oils of aromatic plants as well as chemotaxonomy in the field of plants are welcomed in the journal. All published research articles in Records of Natural Products have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by expert referees.