Antihiperglucémico, antihiperlipidémico y cicatrización de heridas de Boswellia serrata en ratas diabéticas inducidas experimentalmente

Abstract

Diabetes mellitus is a metabolic disorder with complications such as metabolic syndrome and delayed wound healing. In this experimental study, 36 male Wistar rats were randomly divided into three groups: control, diabetic, and diabetic-extract-treated. Twenty four h after the wound was created in the diabetic group treated with topical B. serrata cream 2.5%, and the rats also received aqueous B. serrata extract (400 mg/kg) by oral gavage daily for 3 weeks. Diabetes was induced in the rats by subcutaneous injection of alloxan monohydrate (120 mg/kg). After anesthesia, the full-thickness of the dorsal skin (25 mm × 25 mm) was removed. On days 4, 7, 14, and 21, and wound specimens were collected to evaluate histopathological wound healing. After the treatments, blood samples were collected to measure biochemical factors. Consumption of B. serrata extracts in the diabetic group significantly decreased glucose, liver enzymes, kidney indicators and lipid profile compared to the diabetic control group (P<0.05). Histopathologic studies showed that the rate of epithelial tissue and collagen fibers formation, as well as wound healing, was higher in the group treated with B. serrata than diabetic groups. Hence, it might be useful in diabetic patients, especially the ones with diabetic wounds.