Transdermal Patches for Delivery of Beta-Blockers

European Pharmaceutical Journal Pub Date : 2021-01-01 DOI:10.2478/afpuc-2021-0007

S. Rohaľová, M. Guman, T. Wolaschka

引用次数: 1

Abstract

Abstract Transdermal matrices containing 1.258 mg/cm2 of propranolol and consisting of ethylcellulose (EC), castor oil, and hydroxypropylmethylcellulose (HPMC) or halloysite (HA) were prepared. They were evaluated by tests such as folding endurance, moisture content and absorption, and paddle dissolution test. Of the total amount of propranolol in the samples (20 mg), 28.41% ± 3.30% was released from the EC film after 24 hours, the addition of HA 20.94% ± 1.52% (f1 = 61.82 ± 7.70, f2 = 53.61 ± 4.25) or HPMC 36.05% ± 6.18% (f1 = 34.48 ± 8.79, f2 = 65.02 ± 5.33). The dissolution profiles of HA and HPMC films were compared with each other (f1 = 51.35 ± 12.56, f2 = 59.20 ± 9.43).

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-受体阻滞剂的透皮贴剂

摘要制备了含有1.258mg/cm2普萘洛尔并由乙基纤维素（EC）、蓖麻油和羟丙基甲基纤维素（HPMC）或海洛石（HA）组成的透皮基质。通过耐折性、水分含量和吸收以及桨叶溶解试验等测试对它们进行了评估。在样品（20mg）中，24小时后，从EC膜释放28.41%±3.30%，添加HA 20.94%±1.52%（f1=61.82±7.70，f2=53.61±4.25）或HPMC 36.05%±6.18%（f1=34.48±8.79，f2=65.02±5.33）。比较HA和HPMC膜的溶解特性（f1=51.35±12.56，f2=59.20±9.43）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Pharmaceutical Journal Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： European Pharmaceutical Journal publishes only original articles not previously published and articles that are not being considered or have not been submitted for publication elsewhere. If parts of the results have been published as conference abstract or elsewhere, it should be stated in references. The ethical standards of the Helsinki-Tokio Declaration should be kept. This should be mentioned in the Methods of manuscript. Reviews are published only on request. Authors, whose submitted research work was performed with the support of a company, should indicate this in Conflict of Interest.