Association of uric acid in oral health, periodontal disease, and systemic disorders: A systematic review

Q4 Medicine

Journal of Datta Meghe Institute of Medical Sciences University Pub Date : 2023-07-01 DOI:10.4103/jdmimsu.jdmimsu_89_23

R. B. Uppin, S. Varghese

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引用次数: 0

Abstract

Background: The relationship between periodontitis or periodontal disease (PD) with uric acid (UA) is controversial. Furthermore, a rise in UA levels in common systemic disorders documented to be liked to PD must be understood. Objectives: The objective is to determine the association of UA levels with periodontal health and disease states by a systematic review of evidence from observational studies. Furthermore, we aimed to group secondary research papers which showed systemic diseases linked to periodontitis (SDLP) for the changes in UA levels in serum and discuss the consequences. Materials and Methods: A systematic review was conducted following the guidelines of the Preferred Reporting Items for Systematic Reviews and Meta-analyses statement. The literature search was followed by qualitative assessment using the Newcastle–Ottawa scale when evaluating PD with UA associations. A similar strategic search system was used for identifying secondary studies (systematic reviews with meta-analyses or [SRMA]) for identifying UA levels in common SDLP. Results: Out of 212 selected studies, 40 underwent full-text analysis; 6 were eligible for systematic review. The current review summarizes that overall PD cases have significantly more UA levels than healthy individuals or controls from data from three observational studies. In the case of SDLP, around 8 SRMA (conducted on = 164 observational studies) revealed a significant association (P < 0.05 in all instances) with serum hyperuricemia; cancer incidence and progression were more in women with raised UA than in men. Conclusion: The review showed that UA levels were significantly altered in PD compared to healthy individuals. However, the available evidence is inadequate to establish whether UA is diminished or elevated in periodontal disease. The SDLP all showed a significant association with raised serum UA levels with cancers affecting more women than men with high UA levels.

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尿酸与口腔健康、牙周病和系统性疾病的关系：一项系统综述

背景：牙周炎或牙周病（PD）与尿酸（UA）之间的关系一直存在争议。此外，必须了解在PD喜欢的常见系统性疾病中UA水平的升高。目的：通过对观察性研究证据的系统回顾，确定UA水平与牙周健康和疾病状态的关系。此外，我们的目的是对二级研究论文进行分组，这些论文显示了与牙周炎（SDLP）相关的系统性疾病导致血清UA水平的变化，并讨论了其后果。材料和方法：根据系统评价首选报告项目和荟萃分析声明的指导方针进行系统评价。在文献检索之后，使用Newcastle–Ottawa量表对PD与UA的相关性进行定性评估。类似的战略搜索系统用于确定次要研究（荟萃分析或[SRMA]的系统综述），以确定常见SDLP中的UA水平。结果：在212项选定的研究中，40项进行了全文分析；6例符合系统审查条件。根据三项观察性研究的数据，目前的综述总结出，总体PD病例的UA水平明显高于健康个体或对照组。在SDLP的情况下，大约8项SRMA（在=164项观察性研究中进行）显示与血清高尿酸血症显著相关（在所有情况下均P<0.05）；癌症的发病率和进展在UA升高的女性中多于男性。结论：该综述表明，与健康人相比，PD患者的UA水平发生了显著变化。然而，现有的证据不足以确定UA在牙周病中是减少还是升高。SDLP均显示，血清UA水平升高与癌症有显著关联，UA水平高的女性比男性受影响更多。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Datta Meghe Institute of Medical Sciences University Medicine-Medicine (all)

CiteScore

0.20

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0.00%

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