MORPHOLOGICAL ASPECTS OF FLUORINATED POLYMERS BIOINTEGRATION IN THE EXPERIMENT

V. V. Kudlo, I. G. Zhuk, I. S. Tsydik, N. Prokopchik
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Abstract

Background. There exist strict requirements for polymer materials to be used for implantation into living organisms, thus, no substance lacking negative properties has been found yet. Various groups of polymers are currently under research, including fluorinated polytetrafluoroethylene families. Objective. To evaluate the peculiarities of morphological reactions that occur during implantation of Belarusian fluoroplast-4 into various tissues of experimental animals. Material and methods. The experiments were carried out on outbred white rats weighing 200-250 g, which were divided into four groups. In rats of the first group, a 5×10 mm liver wound was closed with a fluoroplast-4 fragment, in those of the second – with fluoroplast-4 modified by «Photolon» and calcium chloride, in those of the third - a flap of highly porous fluoroplast-4 was implanted into a 5×5×5 mm hip muscle defect, in those of the fourth - a flap of lowporous fluoroplast-4 was used. The morphology of surrounding tissues and that of an implant were studied at various points of time after surgery using light microscopy and morphometry. Results. Surgical trauma resulting from operation on various tissues followed by plasty using fluoroplast-4 activates a sequence of pathomorphological inflammatory-reparative processes, including three classical stages of inflammation and has a reversible character. Polymer materials act as a framework over which the synthetic material is both isolated by collagen fibers and integrated through the ingrowth of the latter into the pores of the polymer, resulting in the formation of a new connective tissue capsule. Conclusions. Fluorinated polymer materials originally manufactured in the Republic of Belarus are biocompatible polymers that can be used in functionally active areas.
形态学方面的氟化聚合物在实验中的生物整合
背景对植入活体的聚合物材料有严格的要求,因此,还没有发现缺乏负面性质的物质。目前正在研究各种聚合物,包括氟化聚四氟乙烯家族。客观的评估将白俄罗斯荧光粉4植入实验动物各种组织过程中发生的形态学反应的特点。材料和方法。实验是在体重200-250g的远交大白鼠身上进行的,它们被分为四组。在第一组大鼠中,用荧光粉4片段闭合5×10 mm的肝伤口,在第二组大鼠(用经“Photolon”和氯化钙修饰的荧光粉4)中,在第三组大鼠中将高度多孔的荧光粉-4皮瓣植入5×5×5 mm的髋肌缺损中,第四组大鼠使用低孔荧光粉4皮瓣。使用光学显微镜和形态计量学在手术后的不同时间点研究周围组织和植入物的形态。后果对各种组织进行手术,然后使用氟质体4进行整形,导致的外科创伤激活了一系列病理形态学炎症修复过程,包括炎症的三个经典阶段,并具有可逆性。聚合物材料充当一个框架,在该框架上,合成材料既被胶原纤维隔离,又通过胶原纤维向内生长而整合到聚合物的孔隙中,从而形成新的结缔组织膜。结论。最初在白俄罗斯共和国制造的含氟聚合物材料是可用于功能活性区域的生物相容性聚合物。
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