Oral Oxycodone Compared With Intravenous Morphine Sulfate for Pain Management of Isolated Limb Trauma; a Randomized Clinical Trial

Emergency Pub Date : 2018-11-18 DOI:10.22037/EMERGENCY.V6I1.22546

Parisa Eizadi, M. Jalili, A. Dehpour

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引用次数: 3

Abstract

Introduction Appropriate pain relief enhances patient satisfaction and reduces patient anxiety. This study aimed to compare oral oxycodone with intravenous (IV) morphine sulfate (MS) in pain management of acute limb trauma. Method In this randomized double-blind clinical trial, patients over 14 years old, with acute isolated limb trauma were randomized to receive either 5mg IV MS or 5 mg oral oxycodone. Pain intensity and adverse effects of medications were recorded 0, 30 and 60 minutes after drug administration and compared between the groups. Result 58 patients were studied. Pain intensity was similar between the two studied groups at 30 minutes (P = 0.834) and 60 minutes (P = 0.880) after drug administration. Furthermore, there was no significant difference between the two groups regarding decrease in pain within the defined time interval. Drowsiness was reported more frequently in MS group after 30 minutes (p = 0.006). Patients in MS group asked for more rescue analgesia. Other adverse effects were similar in both groups. Conclusion Oral oxycodone is as effective as IV morphine sulfate in treatment of acute musculoskeletal pain following blunt limb trauma.

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口服羟考酮与静脉注射硫酸吗啡治疗四肢创伤的疗效比较；随机临床试验

引言适当的止痛可以提高患者的满意度，减少患者的焦虑。本研究旨在比较口服羟考酮和静脉注射硫酸吗啡（MS）在急性肢体创伤疼痛管理中的作用。方法在这项随机双盲临床试验中，14岁以上急性孤立性肢体创伤患者随机接受5mg静脉注射MS或5mg口服羟考酮。在给药后0、30和60分钟记录药物的疼痛强度和不良反应，并在各组之间进行比较。结果对58例患者进行了研究。两个研究组在给药后30分钟（P=0.834）和60分钟（P=0.880）的疼痛强度相似。此外，在规定的时间间隔内，两组在疼痛减轻方面没有显著差异。多发性硬化症组30分钟后嗜睡的发生率更高（p=0.006）。多发性痴呆症组患者要求更多的抢救性镇痛。两组患者的其他不良反应相似。结论口服羟考酮与静脉注射硫酸吗啡治疗钝性肢体创伤后急性肌肉骨骼疼痛疗效相同。

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来源期刊

Emergency EMERGENCY MEDICINE-

自引率

0.00%

发文量

审稿时长

8 weeks

期刊介绍： "Archives of Academic Emergency Medicine" is an international, Open Access, peer-reviewed, continuously published journal dedicated to improving the quality of care and increasing the knowledge in the field of emergency medicine by publishing high quality articles concerning emergency medicine and related disciplines. All accepted articles will be published immediately in order to increase its visibility and possibility of citation. The journal publishes articles on critical care, disaster and trauma management, environmental diseases, toxicology, pediatric emergency medicine, emergency medical services, emergency nursing, health policy and ethics, and other related topics. The journal supports the following types of articles: -Original/Research article -Systematic review/Meta-analysis -Brief report -Case-report -Letter to the editor -Photo quiz