Relationship between Clinical Systemic Lupus Erythematosus Symptoms and Indexes of Blood, Renal Function, Liver Function and Immunology

IF 0.2 4区医学 Q4 MEDICINE, GENERAL & INTERNAL

West Indian Medical Journal Pub Date : 2017-12-22 DOI:10.7727/wimj.2017.148

Q. Lu, H. Yang, Y. Qu, Y. Ding, X. Kang, X. Pu

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引用次数: 1

Abstract

Objective: This paper aimed to study the relationships between clinical systemic lupus erythematosus (SLE) symptoms and indexes of blood, renal function, liver function and immunology. Methods: Total 117 SLE patients were collected, and clinical symptoms and biochemical indexes of blood, renal function, liver function and immunology were determined. Then, adaptive lasso analysis was used to analyse the potential relationship between the clinical symptoms of SLE and biochemical indexes. Results: The present results indicated that pleurisy is closely related to the red blood cells (RBC), haemoglobin (Hb) and urea nitrogen (BUN) with the |βj | values of 0.0045, 0.0168 and 0.0064, respectively; oedema is closely related to the albuminuria and cylindruria with |βj | values of 0.0198 and 0.1170; alopecia has closely correlations with liver damage and aspartate aminotransferase (AST), (|βj | values were 0.0033 and 0.0104); fever is correlated to liver damage (|βj | values were 0.0011); raynaud phenomenon is closely correlated to the triglycerides (TG) and Anti-U1 Ribonucleoprotein (u1RNP) with |βj | value of 0.0012 and 0.0012; facial redness and arthralgia have close correlations with SSA (|βj | value were 0.3580 and 0.0047; arthritis and pericarditis are closely related to antinucleosome antivodies (AnuA) with |βj | values of 0.0038 and 0.0026. Conclusion: The present study indicated that some biochemical, including RBC, Hb, BUN, albuminuria and cylindruria, liver damage, AST, TG, SSA, AnuA and u1RNP, are closely to the prognosis of SLE and it’s important to control these biochemical indexes during the treatment period.

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临床系统性红斑狼疮症状与血液、肾功能、肝功能及免疫学指标的关系

目的:探讨系统性红斑狼疮(SLE)临床症状与血液、肾功能、肝功能及免疫学指标的关系。方法:收集117例SLE患者的临床症状及血液、肾功能、肝功能、免疫学等生化指标。然后采用自适应套索分析法分析SLE临床症状与生化指标之间的潜在关系。结果:胸膜炎与红细胞(RBC)、血红蛋白(Hb)、尿素氮(BUN)密切相关，|βj |值分别为0.0045、0.0168、0.0064;水肿与蛋白尿和圆柱尿密切相关，|βj |值分别为0.0198和0.1170;脱发与肝损害及天冬氨酸转氨酶(AST)密切相关(|βj |分别为0.0033和0.0104);发热与肝损害相关(|βj |值为0.0011);雷诺现象与甘油三酯(TG)和抗u1核糖核蛋白(u1RNP)密切相关，|βj |值分别为0.0012和0.0012;面部发红、关节痛与SSA密切相关(|βj |值分别为0.3580和0.0047;关节炎和心包炎与抗核小体抗体(AnuA)密切相关，其|βj |值分别为0.0038和0.0026。结论:本研究提示RBC、Hb、BUN、蛋白尿、白柱尿、肝损害、AST、TG、SSA、AnuA、u1RNP等生化指标与SLE的预后密切相关，治疗期间应控制这些生化指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

West Indian Medical Journal 医学-医学：内科

CiteScore

0.20

自引率

0.00%

发文量

审稿时长

4-8 weeks

期刊介绍： The Journal is international in scope, with author and editorial contributions from across the globe. The focus is on clinical and epidemiological aspects of tropical and infectious diseases, new and re-emerging infections, chronic non-communicable diseases, and medical conditions prevalent in the Latin America-Caribbean region, and of significance to global health, especially in developing countries. The Journal covers all medical disciplines, as well as basic and translational research elucidating the pathophysiologic basis of diseases or focussing on new therapeutic approaches, and publishes original scientific research, reviews, case reports, brief communications, letters, commentaries and medical images. The Journal publishes four to six issues and four supplements annually. English is the language of publication but Abstracts are also duplicated in Spanish. Most of the articles are submitted at the authors’ initiative, but some are solicited by the Editor-in-Chief. Unless expressly stated, the Editorial Board does not accept responsibility for authors’ opinions. All papers on submission are reviewed by a subcommittee. Those deemed worthy for review are sent to two or three reviewers (one of the three might be a statistician if necessary). The returned papers with reviewer comments are reviewed by the Editor-in-Chief. Papers may be rejected, accepted or sent back to authors for revision. Resubmitted papers from authors are reviewed by the Editor-in-Chief and may be sent back to reviewers or a final decision made by Editor-in-Chief. The decision of the Editorial Board is final with regards to rejected articles. Rejected articles will not be returned to the authors. The editorial subcommittee has the right to return sub-standard manuscripts to the authors, rather than passing them on to the reviewers. This implies outright rejection of the manuscript.