Dose kelofan syrup effective for clinical symptoms and biochemical factorsin COVID-19 patients? A double-blind clinical trials

IF 0.7 Q4 PHARMACOLOGY & PHARMACY
A. Jazani, S. Habibzadeh, Hamidreza Nasimi Doost Azgomi, Alireza Nasimi Doost Azgomi, M. Aghabalaii, R. Nasimi Doost Azgomi
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Abstract

Introduction: COVID-19 is one of the most severe, intestinal, respiratory, and systemic infections in animals and humans. The purpose of this experiment was to evaluate the effect of kelofan syrup on biochemical factors and clinical signs of patients with COVID-19. Materials and Methods: This randomized clinical trial was performed on 60 hospitalized patients with moderate or severe COVID-19. The intervention group received 7.5 cc of kelofan syrup(a traditional Persian medicine product) every 12 hours for one week and the placebo group received 7.5 cc of placebo syrup. Serum levels of white blood cells (WBCs), C - reactive protein (CRP), lactate dehydrogenase (LDH), creatinine, lymphocyte, and clinical outcomes were measured before the beginning of the intervention and on day 7. Results: Kelofan syrup enhanced the white blood cell and reduced creatinine and LDH in the syrup group. However, serum levels of WBC, lymphocyte, CRP, LDH, and creatinine(P > 0.05) in the kelofan group at the end of the study did not significantly change than in the placebo group. Also, clinical outcomes such as fever, respiratory rate, saturated oxygen, cough, dyspnea, myalgia, duration of hospitalization, and fatigue did not change significantly from in the placebo group. Conclusion: our findings indicate that kelofan syrup for seven days could not alter biochemical and clinical outcomes than in the placebo group in patients with COVID-19. However, in some clinical symptoms such as cough, dyspnea, weakness, and biochemical factors like WBC, Cr, and LDH, a significant change was observed at the end of hospitalization in the intervention group.
克罗芬糖浆对COVID-19患者的临床症状和生化因素有效吗?一项双盲临床试验
COVID-19是动物和人类中最严重的肠道、呼吸道和全身性感染之一。本实验旨在评价克罗芬糖浆对新冠肺炎患者生化指标及临床体征的影响。材料与方法:本随机临床试验纳入60例中重度新冠肺炎住院患者。干预组每12小时服用7.5毫升克罗芬糖浆(一种传统波斯医药产品),持续一周,安慰剂组服用7.5毫升安慰剂糖浆。在干预开始前和第7天测量血清白细胞(wbc)、C反应蛋白(CRP)、乳酸脱氢酶(LDH)、肌酐、淋巴细胞水平和临床结果。结果:克罗芬糖浆组大鼠白细胞增多,肌酸酐和LDH降低。然而,在研究结束时,克洛芬组的血清白细胞、淋巴细胞、CRP、LDH和肌酐水平与安慰剂组相比没有显著变化(P < 0.05)。此外,临床结果如发热、呼吸频率、饱和氧、咳嗽、呼吸困难、肌痛、住院时间和疲劳与安慰剂组相比没有显著变化。结论:我们的研究结果表明,与安慰剂组相比,克罗芬糖浆治疗7天不会改变COVID-19患者的生化和临床结果。然而,在一些临床症状如咳嗽、呼吸困难、虚弱,生化指标如WBC、Cr、LDH等,干预组在住院结束时发生了显著变化。
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来源期刊
Journal of Reports in Pharmaceutical Sciences
Journal of Reports in Pharmaceutical Sciences Pharmacology, Toxicology and Pharmaceutics-Pharmacology, Toxicology and Pharmaceutics (all)
CiteScore
1.40
自引率
0.00%
发文量
0
期刊介绍: The Journal of Reports in Pharmaceutical Sciences(JRPS) is a biannually peer-reviewed multi-disciplinary pharmaceutical publication to serve as a means for scientific information exchange in the international pharmaceutical forum. It accepts novel findings that contribute to advancement of scientific knowledge in pharmaceutical fields that not published or under consideration for publication anywhere else for publication in JRPS as original research article. all aspects of pharmaceutical sciences consist of medicinal chemistry, molecular modeling, drug design, pharmaceutics, biopharmacy, pharmaceutical nanotechnology, pharmacognosy, natural products, pharmaceutical biotechnology, pharmacology, toxicology and clinical pharmacy.
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