{"title":"Boundary Layer Effects on Ionic Flows Via Classical Poisson-Nernst-Planck Systems","authors":"Mingji Zhang","doi":"10.1515/cmb-2018-0002","DOIUrl":null,"url":null,"abstract":"Abstract A quasi-one-dimensional steady-state Poisson-Nernst-Planck model of two oppositely charged ion species through a membrane channel is analyzed. The model problem is treated as a boundary value problem of a singularly perturbed differential system. Our analysis is based on the geometric singular perturbation theory but, most importantly, on specific structures of this concrete model. The existence and (local ) uniqueness of solutions to the boundary value problem is established. In particular, an approximation of both the individual flux and the I-V (current-voltage) relation are derived explicitly from the zeroth order approximation (in \") solutions, from which the boundary layer effects on ionic flows are studied in great details.","PeriodicalId":34018,"journal":{"name":"Computational and Mathematical Biophysics","volume":"6 1","pages":"14 - 27"},"PeriodicalIF":0.0000,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1515/cmb-2018-0002","citationCount":"16","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Computational and Mathematical Biophysics","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1515/cmb-2018-0002","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"Mathematics","Score":null,"Total":0}
引用次数: 16
Abstract
Abstract A quasi-one-dimensional steady-state Poisson-Nernst-Planck model of two oppositely charged ion species through a membrane channel is analyzed. The model problem is treated as a boundary value problem of a singularly perturbed differential system. Our analysis is based on the geometric singular perturbation theory but, most importantly, on specific structures of this concrete model. The existence and (local ) uniqueness of solutions to the boundary value problem is established. In particular, an approximation of both the individual flux and the I-V (current-voltage) relation are derived explicitly from the zeroth order approximation (in ") solutions, from which the boundary layer effects on ionic flows are studied in great details.