Application of near-infrared light intensity to determine normal and cancerous breast vessel contrast by gold nanoparticles

IF 1.4 Q4 NANOSCIENCE & NANOTECHNOLOGY
P. Mehnati, Bahman Alipour, R. Salehi
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Abstract

Objective(s): A novel technique for the early diagnosis of breast cancer involves the use of nanoparticles (NPs). The present study aimed to use gold NPs to assess the variations in light source transfer intensity. Materials and Methods: Blood samples with hemoglobin (Hb) concentrations of ×1, ×2, and ×4 were used to simulate normal and cancerous conditions in the breast. Spherical gold NPs (SGNPs) and gold nanorods (GNRs) with various Hb concentrations were injected into the breast phantom, and the intensity of the light transmitted on the wavelength of 635 nanometers was measured. Transmission electron microscopy (TEM) images revealed that SGNPs and GNRs were prepared with a uniform particle shape.Results: When the SGNPs were blended with the Hb concentrations of ×1, ×2, and ×4, the intensity of the passing light from the vessel was estimated to be 3.62, 2.40, and 1.64 mw, respectively. When GNRs were blended with the Hb concentrations of ×1, ×2, and ×4, the intensity changed to lower values 3.42, 2.13, and 1.98 mw, respectively. Conclusion: According to the results, SGNPs and GNRs in normal and cancerous breast induced various passing intensities of Hb concentrations. In addition, the vascular contrast induced by GNRs was higher compared to SGNPs.
近红外光强度在金纳米粒子检测正常和癌性乳腺血管对比度中的应用
目的:应用纳米颗粒(NP)是癌症早期诊断的新技术。本研究旨在使用金纳米粒子来评估光源转移强度的变化。材料和方法:使用血红蛋白(Hb)浓度为×1、×2和×4的血液样本来模拟乳腺中的正常和癌性情况。将具有不同Hb浓度的球形金纳米粒子(SGNP)和金纳米棒(GNRs)注射到乳房模型中,并测量在635纳米波长上透射的光的强度。透射电子显微镜(TEM)图像显示,制备的SGNP和GNR具有均匀的颗粒形状。结果:当SGNP与Hb浓度为×1、×2和×4混合时,来自容器的通过光的强度估计分别为3.62、2.40和1.64mw。当GNRs与Hb浓度为×1、×2和×4混合时,强度分别变为3.42、2.13和1.98mw的较低值。结论:正常乳腺和癌性乳腺的SGNPs和GNRs诱导了不同强度的Hb浓度传递。此外,与SGNP相比,GNRs诱导的血管对比度更高。
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来源期刊
Nanomedicine Journal
Nanomedicine Journal NANOSCIENCE & NANOTECHNOLOGY-
CiteScore
3.40
自引率
0.00%
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0
审稿时长
12 weeks
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