Use of thrombopoietin receptor agonists after hematopoietic progenitor cell transplantation

Sara Singer, Basem M. William
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Abstract

Hematopoietic stem cell transplant (HCT) is used with increasing frequency for the treatment of malignant and nonmalignant diseases. Thrombocytopenia is a common complication following HCT and is associated with decreased survival. Supportive care with platelet transfusion requires significant resources, reduces quality of life, and is associated with several adverse effects including transfusion reaction, infection, and alloimmunization. Thrombopoeitin receptor agonists (TPO-RA) have been found to be safe and effective for the treatment of immune mediated thrombocytopenia, thrombocytopenia related to bone marrow failure syndromes, and thrombocytopenia of chronic liver disease. We hereby discuss in this review the evidence for use of TPO-RA for the management of thrombocytopenia after HCT.

造血祖细胞移植后血小板生成素受体激动剂的应用
造血干细胞移植(HCT)越来越多地用于治疗恶性和非恶性疾病。血小板减少症是HCT后常见的并发症,与生存率降低有关。血小板输注的支持治疗需要大量资源,降低生活质量,并与输血反应、感染和同种异体免疫等多种不良反应相关。血小板生成素受体激动剂(TPO-RA)已被发现是安全有效的治疗免疫介导的血小板减少,与骨髓衰竭综合征相关的血小板减少,以及慢性肝病的血小板减少。因此,我们在这篇综述中讨论了使用TPO-RA治疗HCT后血小板减少的证据。
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